Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living3 Huhti 2019

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Jaksot(234)

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

In this episode of Peak Human, host Brian Sanders interviews Dr. Ted Naiman, discussing the concept of satiety per calorie and its implications for diet and health. They dive into the importance of understanding different diet patterns, focusing on high-protein, nutrient-dense foods, and avoiding overly processed foods. The conversation covers the four pillars of satiety per calorie: protein percentage, energy density, fiber content, and hedonics. Dr. Naman also talks about his new book 'Satiety Per Calorie,' which aims to provide a comprehensive understanding of diet and nutrition, helping people make informed food choices to maintain optimal body composition effortlessly. The episode concludes with discussions on the benefits of natural exercise routines and natural supplements for overall health.   Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show notes   00:28 Understanding Diets and Nutrition 01:28 Exercise and Fitness Insights 02:09 Oyster Pills and Testosterone Boost 03:15 Daily Life and Health Philosophy 03:53 Satiety and Nutrient Density 05:38 The PE Diet and Satiety Per Calorie 06:34 Explaining Diet Patterns and Health Outcomes 12:48 Practical Tips for Diet and Exercise 41:09 Understanding Protein Leverage and Obesity 44:07 Can You Get Fat on Protein? 45:47 Nutrient Calories vs. Energy Calories 49:33 The Four Pillars of Satiety Per Calorie 54:42 The Role of Fiber in Satiety 01:01:38 Energy Density and Caloric Intake 01:07:01 The Liver's Role in Metabolism   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

6 Elo 1h 14min

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

In this episode of Peak Human, host Brian Sanders delves into a comprehensive discussion with marine biologist Stephen Kavanagh, an expert in shellfish and particularly oysters. Brian and Stephen explore the nutritional benefits of oysters, including their historical significance in human evolution and their roles in promoting testosterone, immunity, and overall health. Stephen details his artisanal processes at his facility in Ireland, emphasizing the purity and nutrient density of oysters used in their products. The conversation expands into broader themes of deep nutrition, the slow food movement, and the importance of returning to nature's ratios in our diets. Listeners also receive insights into the issues surrounding processed foods and modern health epidemics like obesity.    Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 02:25 The Journey of Oyster Processing and Supplement Manufacturing 06:02 The Aphrodisiac Effect of Oysters 10:00 Nutritional Benefits and Historical Significance of Oysters 14:18 The Importance of Real Food and Avoiding Processed Foods 15:03 Challenges in the Oyster Industry and Food Lies 20:06 The Synergy of Nutrients and Fortified Foods 26:49 Ancient Diets and the Role of Oysters in Human Evolution 28:48 The Nutritional Power of Oysters 29:41 Evolutionary Benefits of Oysters 31:21 Human Connection to Marine Life 32:17 Oysters and Water Quality 33:01 Oyster Pure: Quality and Testing 34:06 Personal Health Benefits of Oyster Supplements 35:29 Challenges in Marketing Oyster Supplements 43:39 The Slow Food Movement   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Heinä 56min

Part 223 – Mark Sisson on Metabolic Flexibility, Alcohol, Fiber, and the Real Secrets to Longevity

Part 223 – Mark Sisson on Metabolic Flexibility, Alcohol, Fiber, and the Real Secrets to Longevity

Mark Sisson, 72 and still shredded, returns to Peak Human for a powerful conversation on what real healthspan looks like — not chasing 180 years with futuristic tech, but thriving into your 90s with energy, strength, and vitality. As the founder of the Primal Blueprint, Mark brings decades of wisdom on metabolic flexibility, minimalist training, and practical ancestral living. In this episode, Brian and Mark discuss how to optimize metabolism, how to train smarter (not harder), the real deal with fiber, alcohol, hydration, and carbs — and why metabolic flexibility is the key to enjoying life without strict rules, guilt, or orthorexia. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 02:00 The Primal Blueprint and 25 Years of Low Carb Living 04:00 Minimum Effective Dose – Why Mark Hates Overtraining 11:30 Redefining Metabolic Flexibility 14:00 Burning Carbs and Fat – The Joy of Not Being Rigid 18:00 Why Unsustainable Diets Always Fail 20:30 The European Bread Exception – Healing the Gut for Freedom 24:00 Alcohol, Red Wine & the Spectrum of Acceptable Foods 27:30 Fiber is Overrated – Healing IBS with Collagen & Meat 34:00 What Stool Really Is – Busting Fiber Myths 39:00 The Problem with Sugar Diets & Misguided Trends 44:00 You're Not Dehydrated – The Hydration Hype Exposed 49:00 Do We Really Need Electrolytes All the Time? 52:00 Sunlight: Powerful, But Not Without Risk REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

23 Heinä 1h 6min

Part 222 – Metabolic Freedom, Identity Change & the Myth of Snacking w/ Ben Azadi

Part 222 – Metabolic Freedom, Identity Change & the Myth of Snacking w/ Ben Azadi

Ben Azadi joins Peak Human for a powerful, wide-ranging conversation on what it really takes to reclaim your metabolic health in a world of processed food, misinformation, and identity confusion. As the founder of Keto Kamp and bestselling author of Metabolic Freedom, Ben breaks down the biological and psychological barriers to health—from insulin resistance and the dangers of constant snacking to the mindset shifts required to become someone who actually lives in alignment with vitality and longevity. Host Brian Sanders and Ben dive deep into topics like fasting, hormone signaling, body recomposition, and the power of intention. This episode is as practical as it is inspiring, offering a blend of science, ancestral wisdom, and self-mastery. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 01:15 – Meet Ben Azadi: Real food, metabolic freedom, and seed oil awareness 03:10 – The Seed Oil Allergy Card: How to navigate restaurants safely 06:00 – Metabolic Flexibility 101: From sugar burner to fat burner 08:45 – Insulin Resistance is the Root: Why fasting insulin matters more than blood sugar 11:15 – Real vs. Processed Carbs: Potatoes vs. potato chips 13:00 – The Snacking Epidemic: 17 to 23 eating events a day 14:45 – Grazing = Aging: How frequent eating ages you faster 17:30 – mTOR vs. Autophagy: Bodybuilding, aging, and metabolic balance 20:00 – The Hayflick Limit: Cellular aging explained 21:45 – Longevity Mode vs. Growth Mode: Living in cycles 31:15 – Don't Be a Keto Zealot: Even Keto Kamp flexes 36:30 – Nutrient Density Always Wins: Why sugar fasting is not sustainable 40:15 – Metabolic Inflexibility on Both Ends: Fat burners can get stuck too 41:00 – The Diet Culture Trap: Why most diets fail 43:30 – The Subconscious Self-Image: Why your beliefs keep sabotaging you 47:45 – Sticky Note Protocol: The 30-day mental reprogramming 56:30 – Real Food & Movement = Real Results 57:30 – Third World vs. First World: Why simple food wins 58:30 – Final Takeaways: Real food, movement, and mindset still winno REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

9 Heinä 1h 2min

Part 221 - Easy Fat Loss with Natural Hormone Optimization w/ Chris Kruger

Part 221 - Easy Fat Loss with Natural Hormone Optimization w/ Chris Kruger

Chris Kruger returns to Peak Human for an electrifying, no-nonsense breakdown of why the calorie paradigm is broken, how hormone health is the real foundation of lifelong fitness, and what he calls the "Forever Jeans" formula — a simple, powerful way to track your health without lab work or complex diagnostics. In this episode, host Brian Sanders returns after an eight-month hiatus with an update on his documentary 'Food Lies' and a deep dive conversation with fitness expert Chris Krueger. They discuss the myths surrounding diet and exercise, emphasizing the importance of natural hormone optimization over artificial supplementation like TRT. Krueger outlines a holistic approach to health that targets core strength, mobility, balance, and proper nutrition. The conversation also covers practical, actionable insights for achieving optimal health and fitness without the need for extensive gym workouts or rigid diet plans. The episode concludes with practical tips, such as leveraging whole foods and natural supplements like oyster capsules, to naturally boost essential hormones. Show notes: 00:00 Intro – What's New with Brian Sanders & Food Lies 02:15 Hormone Optimization Over TRT – Why Natural Matters 04:25 The Forever Jeans Formula – Waist-to-Height Ratio Simplified 08:55 Hormones vs. Willpower – Why You're Not Broken, the System Is 14:40 You Don't Need a Gym – The 14-Minute Workout That Changes Lives 21:10 Hunger Means Hunter – Rethinking Hunger, Leptin, and Satiety 28:00 The Leptin Trigger – Why Protein is the Key to Real Satiety 33:00 Snacks Are for Fat Kids? – Fasting, Insulin, and Hormonal Wins 35:00 The Flywheel of Hormonal Momentum vs. the Spiral of Willpower 44:20 How Women Can Optimize Naturally – Fat Loss and the 28-Day Cycle 48:00 The Billionaire with a Heart Attack – A Cautionary Tale 55:00 Helpful vs. Unhelpful Foods – A Simpler Way to Think About Diet 01:02:00 The Fitness Industry's Scam – What Really Works REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Kesä 1h 22min

Part 220 - What if Carbs Aren't the Problem? w/ Dr. Randy Johns & Dr. Rob Vasquez

Part 220 - What if Carbs Aren't the Problem? w/ Dr. Randy Johns & Dr. Rob Vasquez

Dr. Rob Vasquez and Dr. Randy Johns, known as The Happy Healthy Guys, wellness experts dedicated to transforming lives through natural health and wellness practices. With a focus on nutrition, detoxification, and holistic living, they aim to empower individuals to achieve optimal health and vitality. Dr. Vasquez and Dr. Johns are passionate about educating others on the importance of a balanced lifestyle, free from toxins and harmful habits. They share their knowledge through online content, public speaking, and wellness programs, helping people across the globe lead happier, healthier lives.   In this podcast episode Dr. Rob and Dr. Randy, share their journey from traditional medical paths to embracing chiropractic care and holistic health approaches. Both doctors recount their personal experiences with health challenges that led them to question the conventional allopathic model, which often focuses on symptom management rather than addressing root causes. Their journey led them to explore various diets and health practices, initially adhering to calorie-restrictive models but eventually shifting towards a more holistic understanding of nutrition. The hosts also discuss their approach to improving metabolic health by addressing common misconceptions and providing practical strategies. They emphasize the importance of metabolic flexibility, explaining how consuming the right types of carbohydrates can actually improve sleep and overall health, contrary to popular low-carb diets. They also talk about the dangers of consuming high-oxalate foods like spinach and almonds, which can lead to serious health issues, including kidney problems. Join their challenge for FREE https://www.h2thinchallenge.com/sapien    Show notes:   [00:02:00] Shift from Allopathic to Chiropractic Care [00:09:00] Trusting the Body's Natural Healing Process [00:11:00] Transition to Nutrition and Metabolism [00:16:00] Evolution of Their Health Philosophy [00:18:00] Rejecting the Calories-in, Calories-out Model [00:20:00] Low Carb Diet Journey,Health Decline and Realization [00:30:00] Reevaluating Dietary Choices [00:37:00] Key Principles for Sustainable Health [00:53:00]High Oxalate foods  [00:55:00] Metabolic flexibility

12 Syys 20241h 19min

Part 219 - Dr. Cate Shanahan on A Root Cause For All Disease?

Part 219 - Dr. Cate Shanahan on A Root Cause For All Disease?

Dr. Cate Shanahan is a board-certified family physician and expert in nutrition, focusing on the intersection of diet and metabolic health. She is the author of Deep Nutrition, The Fatburn Fix, and Dark Calories where she advocates for traditional diets rich in whole foods, emphasizing the benefits of healthy fats and nutrient-dense foods. With a background in biochemistry and genetics, Dr. Shanahan has dedicated her career to understanding how modern processed foods contribute to chronic disease and poor health outcomes. Her work has influenced numerous health professionals and individuals seeking to improve their well-being through dietary changes.

14 Elo 20241h 19min

90 Second Podcast - 3 Amazing Health Transformations

90 Second Podcast - 3 Amazing Health Transformations

Hello everyone, welcome back to Peak Human. This is a different kind of episode. It's going to be three 90 second podcasts. It's my new idea to fill in the gaps between peak human episodes. I do these short episodes with really interesting people I find around the internet with amazing health stories, valuable stuff in 90 seconds, really cool reels. I  put together, put them out on Instagram and also bundle them up and put them out as a little podcast. And so, yeah, in the meantime, go back and listen to the old episodes. Start back at episode one. So many great ones out there. And you may have heard Nose to Tail, my company is not selling meat anymore. We gave it a good run, but there's no profit on real food. I learned how the world works.  The world is the way it is because there's such a high profit margin on processed foods And if you don't have that huge profit margin, it's very hard to stay in business. So we've been supporting our regenerative ranchers here in texas for years now. We're going to sell the last bit of meat this monday We extended it. So if you're listening to this, it's June 12th, we're extending this to Monday, June 17th. And then we're going to stop. But of course we still have our amazing beef tallow body care products, hair, food, skin, food, deodorant, all the things. And we also have our biltong with liver too. We have the sticks made of grass fed meat, made of grass fed beef with liver. Best way to get your organs on the go.  So get that at http://nosetail.org get the last of our pasture raised pork by Monday, June 17th and enjoy the short three podcasts!

12 Kesä 20246min

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