Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living30 Touko 2019

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

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SHOW NOTES

Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
Understanding the fundamental nature of the disease is how we can design an effective treatment
His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
AD is the result of the brain protecting itself from different insults
The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
Paraffin candles produce toxins that damage the brain
Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
Don't wait until it's too late to check for these things, because AD is preventable
Glycotoxicity and how sugar is toxic
Humans are not designed to eat sugar
Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
If AD runs in your family, you should be interested in prevention
AD should be a rare disease
APOE4 is the most common genetic risk factor
If you have a single copy of APOE4 the risk is ~30%
If you have a double copy of APOE4 the risk becomes greater than 50%
For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
21st century medicine is about root cause and prevention
There is no mono-therapy for AD
Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
Don't shake these off as "senior moments"
Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
His diet plan is called "KetoFlex 12/3"
"Keto" for going into periods of ketosis
"Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
"12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
"3" because he wants people to finish eating at least 3 hours before they go to sleep
The Big Four to avoid: grains, simple carbs, dairy, and lectins
He has had amazing success with his patients and has been publishing results since 2014
He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
People who come in with subjected cognitive impairment (SCI) see improvement
People who come in with MCI the majority improve
People with full-blown AD, some people improve and some people don't
He has had people score zero on cognitive tests that have improved
The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
His protocol includes sauna for riding the body of toxins
We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
If you have leaky gut, fix that
The importance of sleep
Current research on macular degeneration
His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
The future of medicine will need to look at how humans were evolutionarily designed to live
You are not powerless to AD, you have control over it
We can reduce the global burden of dementia, we can fight cognitive decline
Find Dr. Dale Bredesen at www.drbredesen.com
His Facebook page https://facebook.com/drdalebredesen/

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Film site: http://FoodLies.org

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Part 177 - Ty Beal on the Top Nutrient Dense Food List & Global Nutrition Solutions

Ty Beal is based in Washington DC as a Research Advisor on the Knowledge Leadership team at the Global Alliance for Improved Nutrition (GAIN). In this role, he supports programmes, research, evaluation, and dissemination of knowledge to stakeholders. He has extensive experience examining sustainable food systems, diet quality, food affordability, food supplies, micronutrient deficiencies, child growth and development, noncommunicable diseases, and global health. He obtained a PhD in Geography with emphasis in Global Nutrition from the University of California, Davis, where he was a National Science Foundation Graduate Research Fellow. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: 00:00- A little bit about who Ty is 01:40- Why should we care about nutrients? 06:30- Ty's studies and the 6 most important nutrients 13:40- The importance of bioavailability and anti nutrients 20:50- Why we should stop fearing animal foods 23:00- Astonishing worldwide deficiency statistics 31:15- What even is a whole grain? 32:40- The food compass 42:15- Nutrient intake and stunted growth 47:00- Discussion on the food environment 52:50- The environmental issue and the future of health 1:00:00- The Eat Lancet diet 1:08:00- The spectrum of healthy diets 1:09:15- Should you eat leafy greens? 1:19:00- Where to find Ty GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

30 Marras 20221h 27min

Part 176 - Decentralization Solving Many of the World's Biggest Problems w/ Matt Grebosky & Brian Sanders

This is a special episode on decentralizing the main areas of society and your life to solve some of the biggest problems we're facing. The big systems are working against us. Most aspects of society are being centralized by corporations and governments at the expense of the individual. For personal health & wealth you should be decentralizing your: - Food/food production - Finances - Health(care) - Community - Education Listen for some practical solutions! Brian Sanders is the filmmaker behind the Food Lies documentary, host of the top 5 nutrition podcast Peak Human, and an international speaker. He graduated from UCLA with a degree in Mechanical Engineering. He works as a Health Coach at Evolve Healthcare and co-founded the health education company Sapien. He also works to spread the awareness of regenerative agriculture and increase access to well-raised animal products through his company Nose to Tail. Matt Grebosky is a CHEK Practitioner, Holistic Health Coach and Head of Operations at Nose to Tail and The Sapien Center. Specializing in ancestral health, nutrition and living, Matt uses a blend of modern science and traditional practices to offer advice on how to approach living a healthy and happy life. Matt studied Holistic Lifestyle and Exercise Coaching at the CHEK Institute in Vista, California after graduating from Penn State University with a degree in Kinesiology. Coaching in various different formats for several years he then transformed his passion for ancestral health to start working for Nose to Tail and eventually The Sapien Center. Follow Matt on Instagram MattGrebosky.com

15 Marras 20221h 11min

Part 175 - Chris Kresser on Why The World is Unhealthy (And What To Do About It)

Chris Kresser, M.S., L.Ac., is a globally-renowned expert, clinician, and educator in the fields of Functional Medicine and ancestral health and the New York Times bestselling author of The Paleo Cure and Unconventional Medicine. He was named one of the 100 most influential people in health and fitness by Greatist.com and has appeared as a featured guest on Dr. Oz, Time, The Atlantic, NPR, Fox & Friends, and other national media outlets. ChrisKresser.com Chris co-founded and co-directed the California Center for Functional Medicine, one of the largest Functional Medicine clinics on the west coast. Throughout his 15-year career he has helped hundreds of patients reverse chronic disease and recover their health and vitality. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES 02:40 - Barriers to proper healthcare consulting 03:50 - How the modern food system is causing Nutrient deficiencies. 05:45 - Why eating healthy might not be enough to combat nutrient deficiencies 11:00 - Can we get enough nutrients in the modern environment? 14:30 - Chris's thoughts on hair mineral analysis testing. 16:45 - The problem with vegan and carnivore diets. 21:50 - Nutrient degradation overtime 25:40- Chris's opinion on oxalates and plant toxins. 28:20- The benefits of eating seasonally 34:50 - Humans have an innate drive to eat certain foods. 39:50 - The nutrient leverage hypothesis. 45:15 - Why we don't know about our nutrient deficiencies. 48:00 - The best ways to maximize the nutrient density of our diets. 57:05 - The issues with the dietary guidelines 59:15 - Chris's opinion on phytonutrients 1:02:30 - Many diets can work to elicit good health. 1:06:30- The height studies 1:13:40 - Practical way to optimize your nutrient status. 1:22:30 - Where to find Chris Kresser GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

9 Marras 20221h 29min

Part 174 - Leigh Erin Connealy, MD on How to Eat to Save Your Life

Leigh Erin Connealy, M.D. is a prominent leader in the Integrative & Functional Medicine medical field. She is the Medical Director of two amazing clinics "The Cancer Center For Healing" & "Center For New Medicine". The clinics have become the largest Integrative Medical Clinic in North America and visited by patients from all over the world with 47,000 patients and growing. She's authored 2 books including "The Cancer Revolution" and was named one of the top 50 functional & integrative doctors in the country in 2017. https://www.connealymd.com/ GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES 0:00- Welcome back Dr. Connealy! 00:06- A picture of what life at Dr. Connealy's clinic looks like 2:03 - How to screen for cancer in the healthiest way. 9:28- The variables cancer patients need to pay attention to. 11:24- A brief aside about the health of the population 12:30- Important practices that Dr.Connealy recommends 19:30 - Dr. Connealy's approach to stress management 21:55 - Why stress is such a big issue in the modern society 27:00 - The last 10 % can make a big difference 32:25- How Dr. Connealy and her team eats. 41:45 - Why proper screening is so important. 49:40- The importance of the internal terrain. GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

2 Marras 202259min

Part 173 - Dr. Leigh Erin Connealy, MD on Treating Cancer with Diet & Lifestyle

26 Loka 202243min

Part 172 - Dan Kittredge on the Amazing Power of Nutrient Density and How to Measure It

Dan Kittredge has been an organic farmer for more than 30 years and is the founder and executive director of the Bionutrient Food Association (BFA), a non-profit whose mission is to "increase quality in the food supply." Known as one of the leading proponents of "nutrient density," Dan works to demonstrate the connections between soil health, plant health, and human health. Out of these efforts was born the Real Food Campaign, now the Bionutrient Institute, which has engineered a prototype of a hand-held consumer spectrometer designed to test nutrient density at point of purchase. Via the Bionutrient Meter, the goal is to empower consumers to choose for nutrient quality and thereby leverage economic incentives to drive full system regeneration. https://www.bionutrientinstitute.org/meetdan BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman SHOW NOTES 00:00 - Dan's upcoming events 00:45- Why should we care about nutrient density? 1:25 - Weston A. Price 1:50 - Why are some foods more nutrient dense than others? 4:08 - Dan's background. 7:02 - The Bio nutrient association. 8:00 - Your body is made up of the foods that you are eating. 9:50 - Nutrient density starts in the soil 14:40 - The modern food environment is blunting our natural instincts for nutrients. 18:40 - Dan's mission to inform the public about nutrient density 33:30 - The sick care system 36:30 - What is spectroscopy? 44:00- Dan's vision for the future 48:00 - The beef project, and how the plants are affecting the quality of the meat. BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

19 Loka 20221h 8min

Part 171 - All my Health Tips/Thoughts in One Place! (Brian Sanders interviewed by Courtney Swan)

This week I'm posting Courtney Swan interviewing me! Her site: https://www.realfoodology.com GET THE MEAT http://NosetoTail.org Topics Discussed: Pre-diabetes Insulin resistance Food pyramid What we got wrong about red meat Veganism Carnivorism Grains How grains changed the way humans evolved History of processed foods Food marketing Climate change How agriculture kills animals too Energy balance consortium Importance of building muscle Healthy state of some indigenous tribes The Maasai people Seed oils Satiety GET THE MEAT http://NosetoTail.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

5 Loka 20221h 10min

Part 170 - Dr. William Davis on the Simple Diet Switches to Change Your Life & Your Gut Health

Dr. William or Bill Davis is a cardiologist, a New York Times #1 bestselling author of the Wheat Belly book series and is the Medical Director and founder of the Undoctored program including the Undoctored Inner Circle, where he helps individuals take back control of their gut, health and lifestyle. Dr. Bill is also the Chief Medical Officer and co-founder of Realize Therapeutics Corp. that is developing innovative solutions for the disrupted human microbiome and author of the book Super Gut GET THE MEAT http://NosetoTail.org SHOW NOTES: [0:25] - Dr. Bill's thoughts on vegetarianism and veganism and the common nutrient deficiencies that accompany the diets [5:00] - Dr. Bill's background, Why he is so outspoken about nutrition and heart health, and the birth of his book Wheat Belly [16:00] - How humans amplified the destructive nature of Grains, Wheat and Soy [28:00] - Modern gut health, measuring microbiota and his book Super Gut [38:05] - Dr. Bill's take on Keto/Carnivore/Low FODMAP diets and their effects on the gut microbiome [45:40] - SIBO, Pre and Probiotics, and creating your own probiotic regiment based on your goals [59:00] - The Hadza, Ancestral diet and Moderns toxins [1:12:20] - Solutions from Dr. Bill to Improve health and your gut GET THE MEAT http://NosetoTail.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

28 Syys 20221h 27min

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