Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

BUY THE MEAT NosetoTail.org

Preorder Food Lies: http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

SHOW NOTES

  • Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
  • Understanding the fundamental nature of the disease is how we can design an effective treatment
  • His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
  • Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
  • AD is the result of the brain protecting itself from different insults
  • The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
  • Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
  • Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
  • He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
  • Paraffin candles produce toxins that damage the brain
  • Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
  • Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
  • For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
  • Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
  • Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
  • Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
  • Don't wait until it's too late to check for these things, because AD is preventable
  • Glycotoxicity and how sugar is toxic
  • Humans are not designed to eat sugar
  • Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
  • Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
  • We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
  • All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
  • If AD runs in your family, you should be interested in prevention
  • AD should be a rare disease
  • APOE4 is the most common genetic risk factor
  • If you have a single copy of APOE4 the risk is ~30%
  • If you have a double copy of APOE4 the risk becomes greater than 50%
  • For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
  • 21st century medicine is about root cause and prevention
  • There is no mono-therapy for AD
  • Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
  • Don't shake these off as "senior moments"
  • Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
  • His diet plan is called "KetoFlex 12/3"
  • "Keto" for going into periods of ketosis
  • "Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
  • "12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
  • "3" because he wants people to finish eating at least 3 hours before they go to sleep
  • The Big Four to avoid: grains, simple carbs, dairy, and lectins
  • He has had amazing success with his patients and has been publishing results since 2014
  • He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
  • People who come in with subjected cognitive impairment (SCI) see improvement
  • People who come in with MCI the majority improve
  • People with full-blown AD, some people improve and some people don't
  • He has had people score zero on cognitive tests that have improved
  • The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
  • Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
  • Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
  • His protocol includes sauna for riding the body of toxins
  • We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
  • Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
  • If you have leaky gut, fix that
  • The importance of sleep
  • Current research on macular degeneration
  • His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
  • The future of medicine will need to look at how humans were evolutionarily designed to live
  • You are not powerless to AD, you have control over it
  • We can reduce the global burden of dementia, we can fight cognitive decline
  • Find Dr. Dale Bredesen at www.drbredesen.com
  • His Facebook page https://facebook.com/drdalebredesen/

BUY THE MEAT NosetoTail.org

Support me on Patreon! http://patreon.com/peakhuman

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Jaksot(233)

Part 169 - How to Fight Big Food, the Banking System & Corporate Control w/ Tristan Scott

Part 169 - How to Fight Big Food, the Banking System & Corporate Control w/ Tristan Scott

Embracing nature, loving the land, and teaching how you can embrace regenerative agriculture and cryptocurrency, Tristan Scott, is the author of the recently released Bitcoin and Beef: Criticisms, Similarities, and Why Decentralization Matters.  Both the regenerative agriculture space and the supporters of Bitcoin have many things in common, such as a disdain for large corporations that only seek to maximize profit, a lack of nuance in local problems and solutions, and deception of the masses.  Tristan brings a factual based argument to many of the myths and solutions that are facing the world today.  Bitcoin and Beef, The Book   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES: [0:20] - Bitcoin & Beef: Why and What? [9:00] - What is Bitcoin and why should you care? [15:30] - What are the downsides to Bitcoin? [21:20] - What is the one thing that could go wrong with Bitcoin? [30:10] - Food systems, global reserves, and food subsidies  [38:45] - The Beef Initiative and the US Beef Market [45:45] - Should we be buying grocery store meat? [53:20] - Can we do this large scale? Stats on Regenerative Agriculture [1:05:50] - Climate, Pollutants and Beef Emissions [1:17:00] - The Bill & Melinda Gates Foundation and African Farming [1:21:40] - 1971 and the getting off the Gold Standard [1:26:00] - How to get involved with your local farmers and get involved in decentralization at an individual level https://www.sovereignhumans.org   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Elo 20221h 42min

Part 168 - Dr. Anthony Chaffee - Do Humans Thrive Most on an All-Meat Diet?

Part 168 - Dr. Anthony Chaffee - Do Humans Thrive Most on an All-Meat Diet?

Dr Chaffee is an American medical doctor and Neurosurgical resident who, over a span of 20+ years, has researched the optimal nutrition for human performance and health. It is his assertion that most of the so-called chronic diseases we treat as doctors are caused by the food we eat, or don't eat, and can be reversed with dietary changes to a species specific diet. He began University at the age of 15 studying Molecular & Cellular Biology with a Minor in Chemistry at the University of Washington in Seattle, which culminated in an MD from the Royal College of Surgeons. Currently in Australia, he specializes in Neurosurgery and does private consultations in functional medicine while thriving on a carnivore diet https://www.patreon.com/thecarnivorelife GET THE MEAT! http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [3:00] - Why Dr. Anthony thinks we are built biologically to be carnivores [10:30] - Why humans don't need teeth and claws to thrive [18:15] - Are we made to eat plants? [25:35] - Why most plants are toxic for you [32:20] - Longevity: Can we live to 120? [45:20] - Blue zones and genetic differences in humans [53:00] - Why are so many groups trying to villainize meat [1:14:00] - Fruit: good or bad? [1:23:25] - Thyroid and Sleep issues on carnivore/keto? [1:35:00] - Organ vs. Skeletal meat ancestrally and in modern times [1:38:10] - Grass-fed vs.Grain-finished GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

17 Elo 20221h 55min

Part 167 - Kate Deering on How to Fix Your Metabolism

Part 167 - Kate Deering on How to Fix Your Metabolism

Kate Deering brings 25 years of experience in the holistic health and wellness space, along with a robust and tested approach to healing someone - nutritionally, mentally, physically and spiritually. With a dense background in sports performance, biochemistry, and physiology, Kate has recently shifted her thoughts on what "true-health" meant, focusing on a more root-cause, holistic approach towards optimal health, while also writing the book "How to Heal Your Metabolism" She often is associated with the likes of Ray Peat and Jay Feldman, embracing fruit, sugar and carbs as a natural and fundamental source of energy, focusing on the underlying issues that leads to intolerances in handling carbohydrates. www.katedeering.com Kate's Instagram GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [0:10] - Recap of the discussion between Kate and Jaime Seeman [4:40] - What is the Ray Peat Diet and Bioenergetic philosophy [9:10] - Stress and energy production [15:50] - Why burning fat may be stressful to the body [22:05] -Long-term stress levels and Type 2 Diabetes [33:15] - OMAD and Protein levels and general macro advice [45:15] - Digestion and nutrient bioavailability [51:55] - Cholesterol - does it matter? [54:30] - Stress, The GI system and exercise [59:20] - Blood sugar, hormones and fruit [1:09:37] - What are the most nutrient dense foods? [1:14:28] - The context of different carb types in the bioenergetic philosophy [1:19:40] - Food logging vs "Intuitive Eating", and overeating [1:31:40] - Does this approach make sense ancestrally? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

10 Elo 20221h 47min

Part 166 - Dave Asprey on How to Navigate the Crazy Modern World

Part 166 - Dave Asprey on How to Navigate the Crazy Modern World

Dave Asprey is the "Father of Biohacking", a 4x New York Times Bestselling Author, the founder of several companies such as Bulletproof and Upgrade Labs, as well the host of the award-winning podcast The Human Upgrade. Dave's mission is to empower the entire globe with information and knowledge that unlocks the Super Human in everyone at any age, working with world-renowned doctors, researchers, scientists, and global mavericks to uncover the latest, most innovative methods, techniques and products for enhancing mental and physical performance. BUY THE MEAT NosetoTail.org SHOW NOTES: [1:20] - Freedom, Rights and Handed-Down Wisdom [10:50] - Consciousness and Food [16:10] - Making Money and Promoting your Brand - Dave's Take [19:30] - How food affects the speed your brain works [24:00] - Conspiracy theories and purposeful lying, and rational action [31:40] - Are CEOs trying to destroy the world or do good? [38:00] - Where should we get fats from? [44:30] - Grass-finished meat, Ancestral Eating and Nutrient Density [53:40] - Plant vs. Animal foods and a dietary framework [1:00:20] - Eat these and stop doing what makes you weak [1:04:20] - The absurdity of "The China Study" and nuance around food [1:08:30] - Dave's thoughts on protein, collagen and digestive enzymes BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

3 Elo 20221h 29min

Part 165 - Jay Feldman on Are You Producing Maximum Energy From Your Diet?

Part 165 - Jay Feldman on Are You Producing Maximum Energy From Your Diet?

Jay Feldman is a health coach, independent health researcher, and host of the Energy Balance podcast. He has degrees in neuroscience and exercise physiology and is devoted to using his knowledge and experience to help people heal from all manner of disease, dysfunction, and difficulty losing excess body fat. To work with Jay you can find him at http://jayfeldmanwellness.com GET THE MEAT http://NosetoTail.org SHOW NOTES: [1:02] - Jay's background and beginnings in nutrition, exercise and health [6:30] - The basis of disease and energy metabolism [9:30] - Insulin resistance, glucose and Jay's stance on low-carb diets [16:30] - Fructose and fatty liver disease [21:05] - Types of carbohydrates, fruit juice and a discussion on glucose spikes [31:20] - Why Jay recommends eating every 3-5 hours [43:35] - General advice for the general population and carbohydrate addictions [52:48] - Overeating, hunger signals why very fat people cannot access their stored energy [53:35] - Gut health and common issues that occur [1:02:00] - Jay's thoughts on paleo and other ancestral diets [1:08:40] - Fat or carbs for fuel? Which is better [1:14:45] - Stress: the good and bad types [1:19:01] - "Why do I need to eat breakfast?" [1:24:56] - Are PUFAs the worst part of the Standard American Diet? [1:31:00] - Is the Bio-Energetic way of eating ancestrally appropriate? GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Heinä 20221h 45min

Part 164 - Farmer Angus on Feeding (and Saving) the World

Part 164 - Farmer Angus on Feeding (and Saving) the World

Big podcast with Farmer Angus who was visiting Austin from Cape Town, South Africa. It was so great to talk in person with someone from halfway around the world who is entirely on the same page. We talk about how good food works, good animal agriculture works, and even how the world works. A great chat with a great guy - don't miss it! GET THE MEAT http://NosetoTail.org SHOW NOTES: [1:45] - The Food Lies Trailer and film update [3:40] - Angus's thoughts on the plant-based narrative and it infiltrating traditional African agriculture [8:45] - Glyphosate and Industrial agriculture [15:03 - What problems and solutions Angus saw visiting farms in the US [20:10] - Angus's thoughts on Weston A Price and his teachings [31:10] - The downward spiral of conventional agriculture and farmers [37:10] - The history and disintegration of Zimbabwe, the "breadbasket" of Africa [41:20] - How we can feed the world [50:30] - Brief overview of Brian's Sapien Compound [55:05] - Fertilizer, methane emissions, and food waste [1:07:42] - The WHY behind Angus's Farm and How they do it GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Heinä 20221h 21min

Part 163 - Jayne Buxton on The Great Plant Based Con

Part 163 - Jayne Buxton on The Great Plant Based Con

On this episode, Brian speaks with the renowned author and journalist Jayne Buxton. Jayne had published several books, non-fiction and fiction, on various subjects, but had a strong passion for regenerative agriculture, nutritional research and advocacy for animal products.  She is the author of the recently released book, The Great  Plant-Based Con, which is discussed today.  Jayne is also an ambassador for The Real Food Campaign and The Public Health Collaboration, while also having written for publications such as The Guardian and The Independent.   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: [3:00] Jayne and Buxton speak on their books/film and what inspired them to start that path [5:15] - Brian and Jayne share their experience with the USDA scientist David Klurfeld  who blew the whistle on the WHO study which demonized Meat  [9:25] - The high-level view of plant-based arguments  [14:10] - Diving into the nutritional differences in omnivore and vegetarian diets and their relation to health [29:30] - the ramifications of Ancel Keys and the demonization of saturated fat, cholesterol and their association to heart disease  [49:40] - The propaganda and narrative behind the environmental arguments in the plant-based agenda  [1:12:00] - Where the globalization behind the plant-based agenda is leading to [1:17:00] - Getting the book and moving forward   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Kesä 20221h 27min

Part 162 - L. Amber O'Hearn on Should Humans Eat Mostly Fat and the Rest Meat?

Part 162 - L. Amber O'Hearn on Should Humans Eat Mostly Fat and the Rest Meat?

Amber O'Hearn has an eclectic background, with academic publications in several fields including theoretical mathematics, cognitive psychology, computational linguistics, and more recently, evolutionary nutrition and biology. She has been studying and experimenting with low-carb, ketogenic diets since 1997, and is particularly interested in evolutionary constraints and interspecies differences. Amber has been eating a nearly plant-free diet since 2009 Ambers Website Mostly-fat.com BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES [1:00] - Amber's background, history, education and interests related to nutrition and a long-term carnivore lifestyle [9:00] - Amber's introduction in 2009 to keto and carnivore through pregnancy [15:45] - Plant antinutrients and health [24:40] - Carnivore + Fruit and Ray Peat [34:35] - "Zooming out" on Plants vs Meat studies and the risks vs costs [42:45] - Plant compounds, antioxidants and oxidative stress [53:00] - Ineffectiveness of RDA's based on individual diets and vitamin deficiencies [1:03:15] - mTOR, Valter Longo, and longevity diets [1:14:30] - High fat diet vs. high protein [1:20:35] - Can the Carnivore community fall into the vegan community nutrient deficiency trap? BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

8 Kesä 20221h 32min

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