10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

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• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1424)

ReWild Yourself! with Daniel Vitalis– Podcast #141

ReWild Yourself! with Daniel Vitalis– Podcast #141

Daniel Vitalis is a nature-based philosopher, specializing in reconnecting people with their “wild” side and empowering them with both ancient and modern strategies for vigorous living. Daniel is the creator of FindASpring.com, a founder of SurThrival.com, and the editor of ReWild Yourself Magazine. He comes on Bulletproof Radio to tell us what ReWilding is, discuss Flintstone-ization and our misconceptions of cavemen, and explain why we are halting human evolution with an overabundance of domestication. Enjoy the show!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Aug 20141h 1min

Mastering Memory with Mattias Ribbing – Podcast #140

Mastering Memory with Mattias Ribbing – Podcast #140

Mattias Ribbing is a three-time Swedish Memory Champion, and one of only 122 people in the world who have been awarded the title of Grand Master of Memory. He is a leading mnemonist, educator, and brain trainer in Sweden, and his memory is officially ranked as the 75th best in the world. Mattias comes on Bulletproof Radio to discuss why brain training is a sport, the impact of diet on memory and focus, and how to take care of both your biological software AND hardware. Don’t miss this episode with one of the world’s foremost memory hackers! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Jul 201453min

The Disease Delusion with Dr. Jeffrey Bland – Podcast #139

The Disease Delusion with Dr. Jeffrey Bland – Podcast #139

Dr. Jeffrey Bland has been an internationally recognized leader in the nutritional medicine field for over 35 years and is known for his ability to synthesize complex scientific concepts in a manner that is both personable and accessible. Jeffrey is on Bulletproof Radio discussing the disease delusion in America and his sought-after book by the same name. Discover why you get sick, the one question to ask when choosing a doctor, why Vitamin E kicks ass, and about Dr. Bland’s 7 core physiological processes. Don’t miss a great episode with the father of “functional medicine”.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Jul 20141h 5min

Geoffrey Miller on Sex, Power, and Domination – Podcast #138

Geoffrey Miller on Sex, Power, and Domination – Podcast #138

Geoffrey Miller is an evolutionary psychologist and a tenured professor at University of New Mexico. Miller is a Fellow of the Association for Psychological Science best known for his books: The Mating Mind and Spent. On this episode of Bulletproof Radio Geoffrey talks in length about human sexual evolution. You’ll hear discussions on shamanism and sex, the male/female orgasm, STD’s, using your breath to improve sexual arousal, and contraception. Also, don’t miss Geoffrey’s answer to the question: “Is sex good exercise?” Enjoy the show!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Jul 201459min

Hashimoto’s: The Root Cause with Dr. Izabella Wentz – Podcast #137

Hashimoto’s: The Root Cause with Dr. Izabella Wentz – Podcast #137

Dr. Izabella Wentz is a clinical pharmacist who was diagnosed with Hashimoto’s in 2009.  Dr. Wentz combined emerging research with clinical expertise to identify and remove the triggers that caused her to develop Hashimoto’s. On this episode of Bulletproof Radio discover new information about the auto-immune epidemic, what Hashimoto’s looks like, and more about the possibilities for a cure. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Jul 201450min

Food for Consciousness with Nora Gedgaudas – Podcast #136

Food for Consciousness with Nora Gedgaudas – Podcast #136

Nora Gedgaudas is a widely recognized expert on the Paleo diet and bestselling author of the book, Primal Body, Primal Mind. On this episode of Bulletproof Radio, discover Nora’s thoughts on human consciousness and food, sugar, resistant starch, psychedelics, and of course Nora’s top 3 recommendations for kicking more ass and being Bulletproof. Enjoy the show, and please share it with your family and friends!   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Jul 201452min

David Gottfried on Explosion Green and Finding Your Impact – Podcast #135

David Gottfried on Explosion Green and Finding Your Impact – Podcast #135

David Gottfried is best known as the father of the global green building movement. He founded both the U.S. Green Building Council and the World Green Building Council (with GBCs in 100 countries) and is on Bulletproof Radio to talk about his insightful book, Explosion Green: One Man’s Journey to Green the World’s Largest Industry. Tune in and hear about how buildings impact your health and performance, hacking your hotel stay, how to find your voice and stay motivated, plus a ton more!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Jul 201445min

Steve Omohundro Talks Technology for a Better World – Podcast #134

Steve Omohundro Talks Technology for a Better World – Podcast #134

Steve Omohundro is a scientist, professor, author, software architect, and entrepreneur doing research on natural and artificial intelligence. He has degrees in Physics and Mathematics from Stanford and a Ph.D. in Physics from U.C. Berkeley.   On this episode of Bulletproof Radio, tune in to discover the secret to Steve’s weight loss breakthrough, why Dave fired his doctor, and how you should define artificial intelligence. You’ll also hear about mycotoxins, transhumanism, and non-violent communication. There are a ton of resources below, be sure to check them out! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Jul 201453min

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