10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

Bulletproof Radio Short Report: Biohacking Tech for Deeper Sleep & Boosting Relaxation – #152

Bulletproof Radio Short Report: Biohacking Tech for Deeper Sleep & Boosting Relaxation – #152

The Bulletproof Radio Short Report is a highly condensed show to quickly bring you the most important ways to upgrade yourself and kick ass at life. This week is about hacking your sleep and energy levels with the Sleep Induction Mat. In this episode, you’ll hear about the benefits of the ancient art of acupressure, how to manipulate your nervous system to maximize relaxation, and how to upgrade your feet and skin (not just your sleep!) with the mat. Enjoy!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Sep 20146min

Uncovering the Science of MCTs & Bulletproofing Your Pets with Melinda Culver – #151

Uncovering the Science of MCTs & Bulletproofing Your Pets with Melinda Culver – #151

Melinda Culver is a veterinarian with a PhD in Animal Sciences from Washington State University. She works for ABITEC, a company that specializes in ester chemistry emulating products found in nature to produce high-quality pharmaceuticals, nutritional supplements, and personal care products, and acts as an advisor to the Horn School for Animal Wellness. Melinda did her dissertation on “The Growth and Development of Muscle and Fat Cells”, and has authored or co-authored over 30 publications, including extensive work using MCT Oil to craft a healthy diet for animals. Why you should listen – This episode is a must-listen for any animal lover! Melinda comes on the show to talk about the science of Medium Chain Triglycerides (MCTs), the optimal diet for your pets, the benefits of MCTs and ketones for animals, and to give a quick lesson on how fats are digested in the body. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Sep 201449min

The Art of Charm on Upgrading Confidence & Enhancing Relationships – #150

The Art of Charm on Upgrading Confidence & Enhancing Relationships – #150

Jordan Harbinger is the co-founder of the wildly popular website where ordinary guys become extraordinary men: The Art of Charm. Jordan is a former lawyer turned relationship coach, and is now the co-host of the Art of Charm Podcast, a top-rated show on iTunes. He has been featured on NBC’s Today Show, in Men’s Health, Cosmopolitan, and Details Magazines, The Huffington Post, and even in Psychology Today. The goal of the Art of Charm is to teach men (and women!) how to take control of their physiology and use better social skills to kick more ass in their relationships, in business, and in life.   Why you should listen –    Jordan comes on the show to talk about why confidence is a skill that can be learned, how to hack your networking & social skills, about the power of good feedback, and why upgrading your communication is important for ALL relationships. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Sep 20141h 3min

Nina Teicholz on Saturated Fats & the Soft Science of Fat - #149

Nina Teicholz on Saturated Fats & the Soft Science of Fat - #149

Nina Teicholz is an investigative journalist and author of the New York Times Best-Selling Book, The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet. She is a well-respected food and nutrition writer that has contributed to publications such as the New York Times, the New Yorker, the Economist, and Men’s Health Magazines, and is a former NPR reporter and associate director for the Center of Globalization and Sustainable Development at Columbia University. Why you should listen - Nina comes on Bulletproof Radio to talk about her book, The Big Fat Surprise, discussing: the truth about saturated fats and their health benefits, a story of failed science and fat, the dangers of oxidized oils, and why our working hypothesis of health isn’t working. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Aug 201458min

Bulletproof Radio Q&A #148 – Podcast

Bulletproof Radio Q&A #148 – Podcast

On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A! Thanks to you, the listener! Hear a thought-provoking conversation and gain a ton of useful knowledge in this episode about the art of biohacking, nutrition, and… well… kicking ass at life in general! Dave and Zak talk about Bulletproof personal care products, whether or not to use supplements with kids, and even demonstrate how to make Bulletproof® Coffee while you’re on-the-go! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Aug 201447min

Hacking Hemp with Anndrea Hermann – Podcast #147

Hacking Hemp with Anndrea Hermann – Podcast #147

If there is anything you ever wanted to know about hemp, cannabis, or marijuana, Anndrea Hermann knows it. She has over 15 years of experience in the Canadian and international hemp industry, including an education in Hemp Ecolonomics, and a Masters degree in the Science of Hemp Agronomy. She owns The Ridge International Cannabis Consulting, is a partner of Hemp-Technologies, and Industry Liaison for Hemp Oil Canada Inc. She has worked in every aspect of the industry, and says that cannabis is part of her final vocabulary. She comes on Bulletproof Radio to talk about eating hemp, wearing hemp, building with hemp, and living hemp dreams. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Aug 201443min

Bulletproof Radio Short Report: 14 Steps to Eating Bulletproof – Podcast #146

Bulletproof Radio Short Report: 14 Steps to Eating Bulletproof – Podcast #146

The Bulletproof Radio Short Report is a highly condensed show to quickly bring you the most important ways to upgrade yourself and kick ass at life. This week is all about the Bulletproof Diet and the 14 steps to know if you want a better body, a clearer mind, and upgraded over all performance. Weather you’re discovering these hacks for the first time or you want a quick refresh on what you already know, this BPR Short Report is a great way to rapidly improve performance. Enjoy!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Aug 201414min

Slinging Superfoods & SuperHerbs with the JingSlingers – Podcast #145

Slinging Superfoods & SuperHerbs with the JingSlingers – Podcast #145

BadAss Blender Biohackers Joy Coelho & Jay Denman are JingMaster Alchemical Culinary Artisans, SuperFood Specialists and Tonic Herbalists. Jay has custom-made more than 50,000 Herbal Elixirs, Tonics and SuperFood Ice Creams. Joy has conjured up thousands of dishes of Organic Superfood, Sugar-free, Gluten-free Creatively Conscious Comfort Food. This dynamic duo biohacks for Red Carpet Clients from the Oscars to the Grammys, upgrading their levels of wellness and longevity. You can have the JingSlingers Upgrade your Jing and Get Slung in person at the 2014 Bulletproof BioHacking Conference, Sept 26th-28th. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Aug 201454min

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