10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1427)

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum  – #160

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum – #160

Leanne Venier is an international award-winning artist, engineer, scientist, and an expert in the science of color and light therapy. She serves as Director of Outreach for the Institute for Neuroscience and Consciousness Studies (INACS), and has lectured at organizations such as MENSA on the healing and consciousness-raising effects of color, light frequencies, and art. She began her career as a mechanical engineer at Lockheed, but is now pursuing her lifelong passion for health by educating medical practitioners, scientists, and lay people about the most up-to-date scientific research in the fields of phototherapy, light/art/color therapy, and biophotonics.   Why you should listen –     Leanne comes on Bulletproof Radio to discuss the role of light and color in health, the problems with fluorescent lighting and working indoors, and how to heal people with biophotonics and different light spectrums. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Okt 201451min

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta is an integrative physician, naturopath, and personal trainer with over 25 years of experience helping people achieve their health, weight loss, and fitness goals. He is the founder & CEO of Metabolic Effect Inc., and author of the best-selling book, The Metabolic Effect Diet. He is a regular contributor to many publications, including The Huffington Post, and the Textbook of Natural Medicine, the number one natural medicine textbook used in medical schools across the country. Jade has completed an estimated 10,000 workouts in his lifetime, and has worked with thousands of weight loss and fitness seekers from all over the world through his Metabolic Effect Clinic and online programs. Why you should listen – Jade comes on Bulletproof Radio to discuss how diets are destroying metabolisms and making people fat, the potential holy grail of weight loss research, the New Laws of Metabolism, and how to become your own diet detective. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Okt 201455min

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi is the CEO of Pavlok, a new biohacking device that helps people change their habits. Maneesh is also the editor-in-chief of the popular blog, Hack the System, a guide to hacking fame, productivity, travel, languages, exercise, and business. He is an experienced biohacker who has become a “famous” DJ in just 90 days, spent a month living in the wilderness for a month with no backpack, and written an international bestselling book by the age of 14!   Why you should listen –     Maneesh comes on Bulletproof Radio to discuss the science of behavior formation, how habit change works, and how to use technology and biofeedback to transform your life for the better. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Sep 201448min

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch is a Doctor of Naturopathic Medicine, and one of the foremost experts in the MTHFR gene and how it affects your health. Ben is the Chief Medical Officer for SeekingHealth.com, an online resource designed to help people optimize their health, reduce their risk of disease, and protect themselves in a world full of toxins. Ben believes that disease is not something you live with, but something that can be overcome, and his practice focuses on helping individuals find the info they need to effectively treat their chronic health conditions, and live healthier, upgraded lives.   Why you should listen –     Ben comes on Bulletproof Radio to discuss the little-known MTHFR gene, why folic acid is dangerous, the different genetic tests and interventions available for the MTHFR condition, and why it is important to look at the whole body and connect the dots between all the metabolic systems in the body. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Sep 201459min

Kelly Starrett: Systems Thinking, Movement Standards, & Getting Ready to Run – #156

Kelly Starrett: Systems Thinking, Movement Standards, & Getting Ready to Run – #156

Kelly Starrett is a coach, physical therapist, author, speaker, and creator of a blog that has revolutionized how athletes think about human movement and athletic performance: MobilityWOD.com. Kelly founded one of the first 50 CrossFit Affiliate gyms, San Francisco CrossFit, and focuses on performance-based Orthopedic Sports Medicine to help athletes, military personnel, dancers, and average Joes achieve elite levels of performance and health. Kelly wrote the New York Times Bestseller, Becoming a Supple Leopard, and his second book, Ready to Run, is available to order now!   Why you should listen –     Kelly comes on Bulletproof Radio to discuss the importance of knowing the difference between addressing a problem instead of the symptoms, why you can’t cheat your physiology, how standing desks in school are benefiting children, and how he is applying human performance principles to public health problems. Enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Sep 20141h 5min

A Second Opinion: Laetrile at Sloan-Kettering with Ralph Moss & Eric Merola – #155

A Second Opinion: Laetrile at Sloan-Kettering with Ralph Moss & Eric Merola – #155

The documentary, A Second Opinion, is debuting at Seattle’s AMC Pacific Place 11 this weekend, Fri-Sun 9/19 – 9/21, and Eric & Ralph will be hosting live Q&As there all weekend. If all shows are sold out for the weekend, AMC will take the film nationwide, so this is a make-or-break opening weekend. If you live in the Seattle area, please go see the movie this weekend! Eric and Ralph will give anyone who mentions that they heard of the film on Bulletproof Radio a free, signed copy of the DVD (with TONS of bonus materials), and admission to the live Q&A’s is free with a ticket stub from the movie theater for the documentary.   A Second Opinion is a documentary by award-winning filmmaker, Eric Merola, about Ralph Moss and his whistleblowing on a massive cover-up involving the unconventional cancer therapy Laetrile at Sloan-Kettering Institute for Cancer Research. Eric has worked for Fuel TV and the WE Network, worked with Michael Moore on the documentary “Capitalism: A Love Story”, and his documentary BURZYNSKI has garnered widespread distribution and numerous international awards. Ralph has written more than 15 books on cancer research, and has received lifetime achievement awards from the American College for the Advancement of Medicine, the Cancer Control Society, The National Foundation for Alternative Medicine, and many other organizations in the cancer education and alternative medicine industries.   Why you should listen –     Laetrile is a natural compound that research showed stopped the growth and spread of cancer, and the info Ralph has to share is shocking for anyone that has ever had their lives touched by cancer. Ralph and Eric discuss the history of the Laetrile cancer treatment, why it was rejected and renounced, and also touch on other exciting new breakthroughs in cancer therapy that people should be aware of. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Sep 201459min

Hacking Trauma, Fear, & Greatness with Lewis Howes – #154

Hacking Trauma, Fear, & Greatness with Lewis Howes – #154

Lewis Howes is an entrepreneur, investor, and athlete. Lewis runs a multi-million dollar online media company, and is the creator of the acclaimed podcast, The School of Greatness, a show that aims to help people find their own path to success. He is a former professional football player, two-sport collegiate All-American, a World Record holding athlete, and currently on the USA Men’s National Team For the Olympic Sport, Team Handball. Howes was recently recognized by Details Magazine as one of the “5 Internet Gurus Who Can Make You Rich”, and awarded as one of the top 100 entrepreneurs in the country under 30 by Empact100 and the White House!   Why you should listen –     Lewis comes on Bulletproof Radio to discuss overcoming adversity, trauma, and fears, how to hack flow states, and the keys to success and achieving greatness in all aspects of your life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Sep 201456min

David Epstein on the Sports Gene & the Science of Extraordinary Performance – #153

David Epstein on the Sports Gene & the Science of Extraordinary Performance – #153

David is the author of The Sports Gene, a book that explores the complex factors that make up a championship athlete. David is an award-winning investigative reporter for ProPublica and Sports Illustrated, focusing on hard-hitting pieces about sports science, medicine, and Olympic sports. He co-authored reports, breaking the Alex Rodriguez doping and Jim Tressel NCAA violations scandals, and is one of the foremost experts on the different factors that impact sports performance.   Why you should listen –     David comes on Bulletproof Radio to talk about hacking expertise, the impact of genetics, doping, and diet in sports performance, whether or not the 10,000 hour rule is legit, and if athletes are really getting better, faster, and stronger. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Sep 20141h 1min

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