10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

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• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Episoder(1424)

#125 Cows Can Save the Planet with Judith Schwartz

#125 Cows Can Save the Planet with Judith Schwartz

In this episode of Bulletproof Radio, you hear from therapist-turned-environmental economist Judith D. Schwartz. Her new book, Cows Save the Planet, is a manifesto about nature’s very own gut - the soil. In this fascinating conversation learn how to reverse desertification, why cow poop is necessary for a healthy ecosystem, and why it’s fundamental to the web of life.     Judith D. Schwartz is a longtime freelance writer and published author. She is an expert in Environmental Economics with an education from Brown University, Columbia University Graduate School of Journalism, and a Master’s in Counseling Psychology from Northwestern. She trained as a psychoanalyst and wrote a novel based on her grandmother’s psychoanalyst who was a member of Freud’s inner circle in Vienna. Judith currently lives and works in southern Vermont and is devoted to sharing her knowledge about cows, soil, and the restoration of the earth’s ecosystem.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Mai 201438min

#124 Resistant Starch Revealed with Richard Nikoley and Tim Steele

#124 Resistant Starch Revealed with Richard Nikoley and Tim Steele

Resistant starch... sounds interesting! And you’ve probably heard mention of it lately, but do you really know what it is? On this episode of Bulletproof Radio, hear Resistant Starch experts, Richard Nikoley and Tim Steele, talk about what it is and how to use it. The show is packed with key insights about how to figure out your own gut biome from potato starch to fecal transplants. Sound gross? It is, and fascinating! Plus you’ll hear the top 3 probiotics we can all start taking right now to improve our gut flora.     Richard Nikoley is a former Navy officer, successful entrepreneur, and creator of the highly informative blog Free The Animal. He is joined by Tim Steele, aka “Tater Tot” (a nickname hinting at his experimentation with potatoes). Tim has helped the re-emergence of resistance starch as a guest writer on Free The Animal and Dr. Grace Liu’s blog, Animal Pharm. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Mai 20141h 1min

#122 Donna Gates on Body Ecology

#122 Donna Gates on Body Ecology

International best-selling author Donna Gates comes on Bulletproof Radio to discuss why gut ecology is vitally important to your performance, and how healing it can be beneficial even for those of us that don’t have digestive problems – but chances are you probably have at least some underlying issues. On the show you’ll learn three things to start doing now for better gut health along with a simple breakdown on which digestive enzymes you should be taking.     Donna Gates is the founder of The Body Ecology Diet, a sugar-free, gluten-free, casein-free, and probiotic-rich way of eating. She is the best-selling author of The Body Ecology Diet: Recovering Your Health and Rebuilding Your Immunity as well as her other books The Body Ecology Guide to Growing Younger: Anti-Aging Wisdom for Every Generation, and Stevia: Cooking with Nature’s Calorie-Free Sweetener. Donna coined the term “Inner Eco-System” over 20 years ago and has since been helping people use probiotics and fermentation to find their individual inner ecology. Enjoy!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Mai 201439min

#121 Brian Rose from London Real: It’s About the Journey

#121 Brian Rose from London Real: It’s About the Journey

In this episode you’ll hear Brian Rose, an American expat and founder of the wildly popular podcast, London Real, an interview series with a stated mission to provide great information, and put BBC TV out of business in the process. You won’t want to miss this kickass talk about sleep hacking, Ayahuasca experiences, and Brian’s favorite biohacking tools.  Plus, at the end of the show you’ll hear Brian answer his own three questions he asks every guest at the end of his own show. Follow Brian on Twitter, @LondonRealTV.     Brian Rose is a former derivatives trader on Wall Street and CFO of a .com startup, with an engineering degree from MIT, and a propensity for pushing the edge. He quit his job as a banker and moved to London to start the podcast London Real. He also hosts Silicon Real for London-based startups. He serves every guest on his show Bulletproof Coffee and says it has a 100% approval rating so far. Enjoy the show.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Mai 201459min

#120 Dr. Terry Wahls on Mitochondria, Health, and Vegetables

#120 Dr. Terry Wahls on Mitochondria, Health, and Vegetables

On this episode of Bulletproof Radio Dr. Terry Wahls talks about the power of food as medicine and how the right nutrition feeds your mitochondria, along with a fascinating breakdown of the origin of mitochondria as bacteria adapting to toxins (oxygen!). You’ll learn how to use glutathione, vegetables, and healthy fats to increase energy and slow aging.     Dr. Terry Wahls is a clinical professor of medicine at the University of Iowa Carver College of Medicine where she teaches internal medicine residents and does clinical research. She was diagnosed with Multiple Sclerosis in 2000 and went from being wheelchair-bound to running on treadmills through her use of nutrition and functional medicine. Her latest book is The Wahls Protocol: How I Beat Progressive MS Using Paleo Principles and Functional Medicine and be sure to listen to her two previous interviews on Bulletproof Radio. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Mai 201456min

#119 Miss Hong Kong on Smart Drugs, Sex, and Singing for Dave

#119 Miss Hong Kong on Smart Drugs, Sex, and Singing for Dave

On this very special episode of Bulleproof Radio meet Miss Hong Kong, Erin Tjoe. Erin talks about her transition from tomboy to runway and how she discovered Bulletproof® Coffee. Also hear Erin’s take on smart drugs, float tanks, bedroom dyads, and how she found bliss at Burning Man. Check out the video version on iTunes and YouTube for an extra special segment with Erin on the Bulletproof® Vibe!     Erin TJOE™, Miss Hong Kong 2014 朱愛倫, is a TV host personality. Her roles include Travel Host of the new show Green Travel Destination, Fashion Host for The LA Fashion, Co-Host of lifestyle talk show Tailor Made, and Entertainment Host/celebrity interviewer for BlacktreeTV. She is also a correspondent at the Sundance Film Festival as well as many red carpet events. Follow her on Twitter, @erinTjoe!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Mai 201433min

#118 Tom Corley, Rich Habits of Wealthy Individuals

#118 Tom Corley, Rich Habits of Wealthy Individuals

Not all habits are created equal, and some can even help you become rich. That’s what Certified Public Accountant and Certified Financial Planner Tom Corley concluded after studying the rich for five years. On this episode of Bulletproof Radio, Tom discusses his bestselling book: Rich Habits and uncovers the most successful daily habits of wealthy individuals. Discover how to optimize your wallet with daily self-improvement, how to change poverty in 30 days, and why the rich don’t gossip.     Tomas C. Corley understands the difference between being rich and poor: at age 9 his family went from being multi-millionaires to broke in just one night. For five years, Tom observed and documented the daily activities of 233 wealthy people and 128 people living in poverty. During his research he identified over 200 daily activities that separated the “haves” from the “have nots.” Tom is a CPA, CFP and holds a Master’s Degree in Taxation.  He is also President of Cerefice and Company, CPAs, one of the top financial firms in New Jersey. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Mai 201455min

#116 Spartan Up! with Joe De Sena

#116 Spartan Up! with Joe De Sena

From cleaning pools for mob bosses to saving the world through extreme endurance and Spartan Racing, Joe De Sena is the CEO and co-founder of the Spartan Race, a series of high endurance and terrifying obstacle courses. On this episode of Bulletproof Radio, entrepreneur and author, Joe De Sena talks about his journey to creating the Spartan Race and: the benefits of pushing yourself to dangerous limits, how to use thermogenesis for recovery, and the effects of ego on performance.  Joe also passes along some very useful running tips! Joe is an impressive guy with quite a few incredible stories. Enjoy!     Joe De Sena is what you might call an extreme endurance racer and radical limit crusher. An entrepreneur from 8 years old Joe has had a passion for life that moves the ball forward against all odds. Born in Queens NY to a yoga teaching, meditation practicing mother and an Italian father that was an uber-entrepreneur the author learned simple techniques for forging ahead no matter the odds. Find out how a young kid breaks out, builds multiple businesses, changes lives, and eventually partners with military SpecOps. Pre-order his new book, Spartan Up!: A Take-No-Prisoners Guide to Overcoming Obstacles and Achieving Peak Performance in Life.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Apr 201453min

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