10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Episoder(1424)

#115 Take Your Power Back with Josh del Sol

#115 Take Your Power Back with Josh del Sol

Electromagnetic fields (or EMFs) are fundamental to the physical world. They occur naturally in the body, but are also man-made and have the potential to affect your performance negatively. Josh del Sol’s award-winning documentary, Take Back Your Power, addresses the performance-robbing effects of certain EMFs and takes a journey into the 2013 NSA spying scandal to expose what he calls “vast programs to monitor your personal communications using ‘smart’ meters.” Josh comes on Bulletproof Radio to discuss his feature film about EMF and radiation standards in America, smart meters, and a possible connection between autism and EMF levels. Check out the shownotes and watch the film online.     Josh del Sol is the Director and Producer of Take Back Your Power, his first feature film.  Born and raised near Vancouver BC, Josh is passionate about the growing movement of social awakening.  He has a vision for a more equitable social structure, with decentralized energy production and foundational values which honor the sanctity of life and human rights.  Josh finds inspiration in those of courage who speak truth to power, from a place of non-violence and vision, laying the foundation for necessary solutions. Follow @TBYPfilm on Twitter.   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Apr 201450min

#114 Marc David Hacks into the Psychology of Eating

#114 Marc David Hacks into the Psychology of Eating

Bestselling author and founder of the Institute for the Psychology of Eating, Marc David has made it his life’s work to help people do exactly what they say they want to do. On this episode of Bulletproof Radio, Marc goes deep into the psychology of eating and explains some of the easiest ways to hack your nutrition and perform better when you eat with integrity. You’ll discover why Marc says: “You cannot be a food addict,” along with how to make sense out of trauma, why the obesity paradox is a black eye in the face of science, how potato chip companies are capitalizing on our dental aggression habits, and a ton more!     Marc David is the Founder of the Institute for the Psychology of Eating, a leading visionary, teacher and consultant in Nutritional Psychology, and the author of the classic and bestselling books Nourishing Wisdom and The Slow Down Diet.  His work has been featured on CNN, NBC and numerous media outlets. The Institute for the Psychology of Eating is the world’s only teaching organization dedicated to a forward thinking, positive, holistic approach to nutritional psychology. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Apr 20141h 2min

#113 Dr. Cate Shanahan and Bulletproofing the NBA

#113 Dr. Cate Shanahan and Bulletproofing the NBA

Dr. Cate Shanahan is using Bulletproof Diet principles to help pro athletes perform better. On this episode of Bulletproof Radio, physician, author, and LA Lakers Nutrition Director, Dr. Shanahan, talks how she transforms the diets of NBA stars like Dwight Howard and gets them to exchange nachos for charcuterie - one step at a time. Also hear Cate explain gluten on a molecular level and she makes a powerful argument for why consuming vegetable oil is like eating radiation. The show also includes information on: sugar addiction, milk proteins, and the benefits of eating, “meat on the bone”.     In addition to her thriving Napa Valley medical practice, Cate Shanahan, MD is Nutrition Director of the Los Angeles Lakers PRO Nutrition program. Before attending Robert Wood Johnson Medical School and specialty training at University of Arizona’s Family and Community Medicine, she studied genetics and biochemistry at Cornell. Her background enabled her to recognize the flaws in mainstream nutrition theories and fill in the gaps in most popular diets. She has worked with patients to achieve lasting weight loss, optimal sports performance, and elimination of medication dependence through a systematic approach. Like Dr. Cate on Facebook!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Apr 201454min

#112 AJ Jacobs on His Life as an Experiment

#112 AJ Jacobs on His Life as an Experiment

Bestselling author and renowned NYC journalist, AJ Jacobs is a living, breathing experiment. On this episode of Bulletproof Radio, AJ reveals his methods behind hacking into (what he calls) the three domains of self-improvement. Jacobs talks about his quest to become the smartest person, what happened when he lived (quite literally) according to the Bible, and his humble quest for bodily perfection. Also catch tips on how to act your way into a new way of thinking. Enjoy!     A.J. Jacobs is an author, journalist, lecturer and human guinea pig. He has written four New York Times bestsellers that combine memoir, science, humor and a dash of self-help. He is also editor at large at Esquire magazine, a commentator on NPR and a columnist for Mental Floss magazine. His first book is called The Know-It-All: One Man’s Humble Quest to Become the Smartest Person in the World (Simon & Schuster, 2004). The memoir — which spent two months on the New York Times bestseller list — chronicles the 18 months Jacobs spent reading the entire Encyclopedia Britannica in a quest to learn everything in the world. It was praised by Time magazine, Newsweek, Vanity Fair, USA Today, Janet Maslin in the New York Times and AJ’s uncle Henry on Amazon.com. Follow him on Twitter @ajjacobs! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Apr 201448min

#111 Olympian Bree Schaaf talks Staying Bulletproof at Sochi

#111 Olympian Bree Schaaf talks Staying Bulletproof at Sochi

Olympian turned NBC analyst, Bree Schaaf talks staying Bulletproof while at the Sochi Olympics last month. Bree has been competing in sliding sports for the past 12 years. Just now back from Russia, Bree’s on Bulletproof Radio to discuss skeleton bobsled racing, her kickass routine for high performance, how she recovered from hip surgery, selenium toxicity, and more. Hear about how she didn’t let even the TSA keep her from eating a Bulletproof Diet during the games.     The former Portland State University Volleyball player spent her first five years on ice as a skeleton athlete before becoming a bobsled pilot.  Schaaf has earned 13 top-10 finishes on the World Cup circuit and finished fifth with brakeman Emily Azevedo at the Vancouver 2010 Olympic Winter Games. Schaaf is the first American female to compete in both a Skeleton World Championships as well as Bobsled World Championships.   Coming up just short at Olympic Trials this year, Schaaf not only be attended the Sochi 2014 Olympics as alternate, but made her NBC Olympics broadcast debut as a skeleton analyst and sliding sports correspondent.     ·           0:10 – Cool Fact of the Day! ·           0:30 – Welcome Bree Schaff ·           1:01 – What is skeleton? ·           3:57 – Traveling to Russia with butter and MCT ·           8:25 – Bree’s routine for high performance ·         10:50 – Hip surgery recovery and Bulletproof ·         14:05 – Finding glutes under the “lady fat” ·         14:35 – Bio-hacking menstrual cycle ·         18:00 – Testosterone envy ·         19:10 – Competitive drive ·         23:30 – Karaoke flow state ·         26:30 – Cholesterol ·         27:00 – Selenium toxicity ·         29:40 – Mental training and meditation   ·         39:05 – Top three recommendations for kicking more ass and being Bulletproof! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Apr 201445min

#110 CrossFit Master Shana Alverson Makes Strong The New Skinny

#110 CrossFit Master Shana Alverson Makes Strong The New Skinny

One of the 50 fittest women in the world comes on Bulletproof Radio to talk about how strong is the new skinny and how she became a major player in the CrossFit community. On this episode of Bulletproof Radio you’ll get a look inside the mind of a real CrossFit master and she’s sassy too. Alverson talks about her strict adherence to a Paleo diet, her thoughts on women and ketosis, and if she thinks it’s okay to do CrossFit while pregnant. Get the show below!     Shana Alvesrson owns Crossfit East Decatur in Georgia. She is a level 1 Certified CrossFit trainer as well as a Level I CrossFit Running & Endurance Certified. Shana also trains in CrossFit Olympic lifting, movement & mobility, gymnastics, and Crossfit kids. Her passion for the gym began at 15 after discovering how nutrition and exercise elevated her mood. She has been teaching people how to exercise since 1995, and in 2007 began her CrossFit training career. Catch her kicking ass a CrossFit East Decatur and on Twitter @ShanaAlverson. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Apr 201441min

#109 Steven Kotler and The Rise of Superman

#109 Steven Kotler and The Rise of Superman

Have you ever experienced a flow state? It’s the superhuman state of high performance when everything is in-sync and you’re kicking ass at life? Bestselling author of The Rise of Superman, Steven Kotler, will teach you how to find your flow state and stay there. In this episode of Bulletproof Radio, Kotler breaks down the 3 psychological conditions for flow state, the 4 stages of flow, and how to turn it on and off. Steven also tells a great story about his own flow state experiences as a writer, his battle with Lyme disease, and discusses, The Flow Genome Project.     Steven Kotler is a New York Times bestselling author, award-winning journalist, and co-founder and director of research for the Flow Genome Project. His books include The Rise of Superman, Abundance, A Small, Furry Prayer, West of Jesus, and The Angle Quickest for Flight. His work has been translated into thirty languages and his articles have appeared in more than seventy publications, including the New York Times Magazine, Atlantic Monthly, Wired, and Forbes. You can find him online at stevenkotler.com or writing Far Frontiers, a blog for Forbes.com: www.forbes.com/sites/stevenkotler. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Apr 20141h

#108 Dr. Sara Gottfried – The Hormone Cure

#108 Dr. Sara Gottfried – The Hormone Cure

Owning your hormonal health is crucial to performance, and this goes for all the sexes. M.D. and bestselling author of “The Hormone Cure,” Dr. Sara Gottfried joins Bulletproof Radio to underscore the importance of leveraging hormones and how to uncover the velvet vulva. Dr. Sara relies on results-based data and her own practice as a physician to define her theory on why women often struggle on high-fat diets and often take a dive off a hormonal cliff. On this show you’ll learn about monitoring your brain chemical three-some, feeding the gut bacteria you want, and how birth control pills can affect sexual attraction.     Dr. Sara Gottfried M.D. is a Harvard-educated physician, speaker, yoga teacher, wife, mom of two daughters, and author of the New York Times bestselling book, The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality with The Gottfried Protocol (Simon & Schuster, 2014). She’s also a board-certified gynecologist and the creator of an awesome new online program called Mission Ignition: The Energy Cure. For the past 20 years, Dr. Gottfried has been dedicated to helping women feel back home in their bodies. Like Sara on Facebook! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Mar 201452min

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