10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

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• My Daily Supplements: SuppGrade Labs (15% Off)

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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Episoder(1430)

How Breast Implants Compromise Your Health and Make You Sick – Dr. Robert Whitfield MD : 1043

How Breast Implants Compromise Your Health and Make You Sick – Dr. Robert Whitfield MD : 1043

Here's what you must know about the health risks and extensive symptoms of breast implant illness, as well as removal solutions. Dr. Robert Whitfield MD discusses the often-overlooked health risks associated with breast implants. Women who experience breast implant illness have symptoms like brain fog, memory loss, fatigue, joint pain, anxiety, and many more.While there’s not a definitive cause of breast implant illness, a common theory points to an immune system response. Breast implants in the body can lead to persistent foreign body reactions, silicone toxicity, heavy metal exposure, biofilm development around the implants, and free radical/oxidative damage. Over time, these reactions weaken the immune system and cause health symptoms from minor to severe. Your autoimmune response, endocrine system, thyroid & adrenals, and gut all could be affected.Dr. Robert Whitfield MD’s an Austin-based plastic surgeon who’s cared for hundreds of women with breast implant illness, performs breast explants, and teaches other surgeons about this illness and treatment methods. In his years of experience in breast reconstruction for cancer patients, microsurgery, and a deep understanding of the body's reactions to foreign materials, he's developed a unique insight into the world of breast implant illness.This episode serves as a guide to what could be happening in your body, what symptoms to watch for, and breast implant removal options if you suspect you may have breast implant illness. Get more information and take a quiz at https://breastimplantillnessexpert.com and share this important episode with your spouse, a family member, a friend, or a colleague.Watch this episode on YouTube! Find all the links and resources in the show notes. WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Must-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discountFeel Dangerously Good! Discover the energy, focus and performance that come from mineralized coffee designed with your biology in mind. Your cells will thank you. dangercoffee.com, use code DAVE15 to save 15%Vitamin DAKE & Minerals 101: Foundational vitamins and essential minerals that do the most good across every system in your body. vitamindake.com, use code DAVE10 to save 10%See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Apr 20231h 5min

A Guide to Strengthening & Healing Your Adrenals – Izabella Wentz, PharmD.  : 1042

A Guide to Strengthening & Healing Your Adrenals – Izabella Wentz, PharmD. : 1042

Get actionable expert tips on testing, nutrition, and lifestyle changes you can do to achieve peak adrenal function. Izabella Wentz, PharmD., aka the “Thyroid Pharmacist,” takes on adrenal fatigue, its symptoms, and the importance of fixing adrenal function in addition to treating thyroid issues in her new book, “Adrenal Transformation Protocol: A 4-Week Plan to Release Stress Symptoms and Go from Surviving to Thriving.”She went deep into the research to develop an actionable guide for you. Her new book helps you identify and mitigate the effects of adrenal dysfunction. If you’re experiencing low energy, insomnia, brain fog, anxiety or burnout, your adrenals may be overworked.You’ll learn why adrenal, immune, and thyroid issues develop as an adaptive mechanism to protect you in times of danger.You’ll also learn how to manage four big stressors that influence your adrenals in a negative way.You’ll find out what lifestyle and mindset changes you can make that turn off danger signals and communicate safety messages to your body.Her protocol emphasizes providing the body with more safety signals to counteract the stress response. She recommends dietary changes, anabolic-focused exercises, and supplements such as carnitine. She also explains the role of adrenal dysfunction in allergies and histamine issues, the dangers of B6 supplements, and the importance of balancing sodium and potassium intake for adrenal health. She suggests Epsom salt baths, a cold bedroom, and paying attention to factors such as H. Pylori, malabsorption, and the CBS gene mutation to address ammonia levels in the body.If you suspect your adrenals are on the fritz, Izabella stresses the importance of a varied and holistic approach to treatment. She urges proper testing and diagnosis of adrenal dysfunction and thyroid issues to build resilience in your body.Watch this episode on YouTube!Find all the links and resources in the show notes. WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Micronutrients Boost HRV: https://modemethod.com, use code DAVE to get 15% off your first orderFeel Dangerously Good! Discover the energy, focus and performance that come from mineralized coffee designed with your biology in mind. Your cells will thank you. Go to dangercoffee.com, use code DAVE15 to save 15%Vitamin DAKE & Minerals 101: Foundational vitamins and essential minerals that do the most good across every system in your body. Go to vitamindake.com, use code DAVE10 to save 10%See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Apr 202354min

Upgrade Spotlight: How Nitric Oxide Controls Oxygen & Nutrient Delivery, Aging, and Quality of Life – Pneuma Nitric Oxide : 1041

Upgrade Spotlight: How Nitric Oxide Controls Oxygen & Nutrient Delivery, Aging, and Quality of Life – Pneuma Nitric Oxide : 1041

Learn about nitric oxide’s crucial role in your body systems, how to naturally produce more of it, and how to supplement effectively and safely. Research scientist Nathan Bryan, Ph.D., has been involved in nitric oxide research for the past 25 years and has made many discoveries in the field. He’s an international leader in molecular medicine and nitric oxide biochemistry. You'll find out how nitric oxide works within major body functions and what you can do to increase your body's natural production of it.Pneuma Nitric Oxide sponsored this episode.Human performance depends on sufficient oxygen and nutrient delivery to organs, tissues, and cells so they can do their job. Nitric oxide controls oxygen and nutrient delivery. It’s now recognized “as one of the most important molecules produced in the body of humans,” Nathan says. “It's a vasodilator, so it controls the regulation of blood flow. It's what's responsible for oxygen and nutrient delivery to every organ, tissue, and cell in the body.”That’s why it’s so important to find the right carrier to effectively deliver this complex and bioactive gas that’s gone in less than a second. Nathan was one of the first scientists to develop a technology to make a solid dose form of nitric oxide.He shares information about Pneuma Nitric Oxide’s key products, like its lozenges, and the N1O1 skincare line. The lozenges open small blood vessels internally and the topicals open superficial blood vessels on the skin to improve blood flow and cellular turnover. He explains how to use a nitric oxide-generating serum on your skin from his N1O1 skincare line that enhances blood flow and promotes wound healing. Nathan presents the anti-aging, performance-enhancing, and nootropic benefits of nitric oxide along with its role in improving stem cell function, controlling telomerase activity, and improving mitochondrial function.He identifies the different isoforms of nitric oxide for you, noting that you should choose a nitric oxide supplement that delivers the same amount of nitric oxide that the body would normally produce. He emphasizes the importance of restoring the body's ability to naturally produce nitric oxide and debunks the use of nitric oxide precursors such as L-arginine and citrulline. He also stresses using safe and effective nitric oxide products.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://n1o1.com and use code DAVE to get 10% off and free shipping.Watch this episode on YouTube! Find all the links and resources in the show notes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Apr 202330min

How 10 Elements of Joy Improve Your Outlook and Performance – Legacy Upgrade ft. Ingrid Fetell Lee : 1040

How 10 Elements of Joy Improve Your Outlook and Performance – Legacy Upgrade ft. Ingrid Fetell Lee : 1040

IN THIS EPISODE OF THE HUMAN UPGRADE™... a legacy upgrade conversation with Ingrid Fetell Lee gets into the topic of joy and the influence of your surroundings on your emotions and well-being. You may be hacking your body and mind, but are you embracing joy along the way? This episode shows you how—and explains why it’s essential. You’ll also find out the difference between happiness vs. joy. Fun Fact: While you may be able to fake a smile, you can’t fake joy.Ingrid brought joy into the popular culture conversation with her book, “Joyful: The Surprising Power of Ordinary Things to Create Extraordinary Happiness.” She’s a designer, author, TEDtalk speaker and founder of “The Aesthetics of Joy.” Her work empowers people to find more joy through the purposeful and emotion-driven design of their environments. She’s identified 10 elements of joy that resonate with nearly everyone.EnergyAbundanceFreedom HarmonyPlaySurpriseTranscendenceMagicCelebrationRenewalIngrid explains how to recognize, feel and incorporate more joy into your everyday life.FREE JOY RESOURCES: Downloadable guides: 50 Ways to Find Joy Every Day and Joyspotter’s GuideWE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Electrolytes That Taste Good With Zero Sugar Hydration: https://drinklmnt.com//dave, get a FREE LMNT Sample PackGet Your Tickets! 9th Annual Biohacking Conference: https://biohackingconference.comDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” is out now. https://daveasprey.com/books/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Apr 20231h

How Discovering Your Own Genius & Creativity Will Unlock Your Full Potential – Ozan Varol : 1039

How Discovering Your Own Genius & Creativity Will Unlock Your Full Potential – Ozan Varol : 1039

IN THIS EPISODE OF THE HUMAN UPGRADE™… former rocket scientist and former law professor Ozan Varol—an expert in creativity, innovation, and critical thinking—says that unlocking your full potential involves reimagining the status quo rather than simply resisting it. “The word resist for me gets in the way because often resistance becomes a different way of conformity, as in you're resisting something but you're not really offering a new path forward,” he says. “So, resistance becomes its own end in and of itself. The goal should be re-imagination.”In this discussion about Ozan’s newest book, “AWAKEN YOUR GENIUS: Escape Conformity, Ignite Creativity, and Become Extraordinary,” you’ll learn to access the best parts of your brain and create your own path as a leader and creator by acting instead of reacting. While people consider those who blaze their own trail as geniuses, Ozan contends that genius is not limited to a select few. Rather, it can be discovered by anyone. He loaded this book with smart tips, examples, things to think about, and things to do. For example, you’ll learn why you should ignore email until noon and spend the most valuable time of your day thinking in creativity. You’ll also learn how spending more time on the “why” than the “what” moves you toward the life you really want to be living. He lays out an action roadmap for you to cultivate your own genius and be in charge of your time and creativity.Watch this episode on YouTube!Find all the links and resources in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% off Feel Dangerously Good! Discover the energy, focus and performance that come from mineralized coffee designed with your biology in mind. Your cells will thank you. https://dangercoffee.com, use code DAVE15 to save 15%Vitamin DAKE & Minerals 101: Foundational vitamins and essential minerals that do the most good across every system in your body. vitamindake.com, use code DAVE10 to save 10%See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Apr 20231h

Hacking the ‘Middle-Age Spread’ – Interventions With Dave – David Hinds : 1038

Hacking the ‘Middle-Age Spread’ – Interventions With Dave – David Hinds : 1038

In this Episode of The Human Upgrade™...​ Dave talks to David Hinds of Brisbane, Australia, about gut issues and weight loss for men at mid-life. David’s already biohacking, working out, and taking supplements he thinks are the right ones—yet the weight around his mid-section persists.This intervention looks at ways to tackle hard-to-budge love handles and extra mid-section weight with suggestions covering hormones, thyroid, sleep, SIBO, probiotics, supplements, inflammation, the pituitary gland, prolactin, and potassium. This discussion gets into libido and eyesight, too.David’s in his early 50s and a dad to two teenagers. He started biohacking over three years ago when he discovered the Bulletproof Radio podcast (now called The Human Upgrade). He then read Dave’s books, made some life changes, saw the results, and decided 150 years on this rock would be awesome! “So, I'm one-third of the way through life, and my aim is to be in the best physical and mental state possible for all of those years,” he says.Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.Find a full list of the Interventions With Dave episodes here.Listen to this episode on YouTube!WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Protein Bars with All the Good Stuff and None of the Crap: https://rowdybars.com, use code DAVE to get 10% offKickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planNature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Apr 202335min

How to Heal Your Gut: Exploring the Latest Bacterial Science and New Treatments – Vincent Pedre, M.D. : 1037

How to Heal Your Gut: Exploring the Latest Bacterial Science and New Treatments – Vincent Pedre, M.D. : 1037

IN THIS EPISODE OF THE HUMAN UPGRADE™… Vincent Pedre, M.D., explains how consuming too much sugar can lead to insulin resistance and diabetes by causing shifts in the microbiome that reduce insulin signaling. He also highlights how omega-6 fats found in processed foods contribute to inflammation and chronic disease by carrying lipopolysaccharide toxins through cell membranes. For over a decade, board-certified internist and Functional Medicine certified practitioner, Dr. Pedre, founder of Happy Gut Life, has helped people improve their well-being and quality of life by building the foundation of gut health that supports total physical and mental wellness. He believes that healing begins in the kitchen through the foods we eat. He brings together years of research and clinical experience to offer you real solutions in his newest book, “The GutSMART Protocol: Revitalize Your Health, Boost Your Energy, and Lose Weight in Just 14 Days with Your Personalized Gut-Healing Plan.”The balance between good and bad bacteria is both important and nuanced—more microbial diversity in the gut is not always better. "The focus should be on metabolomics, not just diversity when it comes to gut bacteria,” Dr. Pedre says. Another focus includes gut interrelationships and the seven big systems in your body affected by leaky gut: skin, airway, brain, joints, energy, metabolism, and immune system.Watch this episode on YouTube!Find all the links and resources in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Anti-aging Powerhouse: https://spermidinelife.us/dave , use code DAVE25 to save 25% on your first purchaseMust-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discountDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” is out now. https://daveasprey.com/books/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Apr 20231h 9min

Detox Your Home: How to Improve Indoor Air Quality & Get Rid of Mold – Michael Rubino : 1036

Detox Your Home: How to Improve Indoor Air Quality & Get Rid of Mold – Michael Rubino : 1036

IN THIS EPISODE OF THE HUMAN UPGRADE™… An air quality expert explains the impact of your home environment on your health, mold sensitivities, and the remediation process, including DIY tips and professional interventions. You’ll also find out about The Dust Test, which identifies mold, bacteria, and biotoxins in your home so the inspector can remove all sources of contamination.Mold is likely a problem in your home, as it is for many people, and you likely don’t know what to do about it. Every year, mold damages property and costs homeowners money. But worse than that, mold is dangerous to your health, especially if you are one of 375 million Americans who are susceptible to chronic mold sensitivity. With decades of field experience, Michael Rubino, president of HomeCleanse, excels at working with individuals—many of whom are who are immunocompromised—to detoxify their homes and improve indoor air quality. He has helped more than 1,000 families heal from toxic mold exposure so far, and, as he says, this is just the beginning.Through scientific expertise and innovation, Michael developed alternative remediation protocols that eliminate common mold sources and eradicate the contamination caused by those sources.His expert advice in this episode is a go-to resource for anyone worried about an increasingly common problem that can have life-threatening side effects. And his book The Mold Medic can definitely help you breathe easier. SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to www.thedusttest.com/dave and use code DAVE to get $10 off. Watch this episode on YouTube! Links and resources can be found in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% off Get Your Tickets! 9th Annual Biohacking Conference: https://biohackingconference.comDave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want.” https://daveasprey.com/booksSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Mar 202348min

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