80: Genome sequencing predicts outcomes after congenital cardiac surgery
Watkins WS et al et al., Nature Communications - A prospective observational study of 2,253 Pediatric Cardiac Genomics Consortium patients shows that whole-exome sequencing combined with AI genome int...
19 Jul 202516min
79: Cross-population GWAS and Proteomics Reveal AF Mechanisms and Better Risk Prediction
Nature Communications - A large cross-population GWAS meta-analysis (168,007 AF cases) integrated with proteomic data identifies hundreds of AF loci, implicates cardiac and TGF-β pathways, finds causa...
18 Jul 202517min
78: Unloading Lipids: TTYH2 Meets APOE
Sukalskaia A et al., Nature - This Nature study identifies APOE as an interaction partner of human TTYH2, maps their endosomal colocalization and binding site by cryo-EM, and shows that TTYH2 accelera...
17 Jul 202514min
77: REX: a range extender for long-distance enhancer activity
Bower G et al., Nature - This paper identifies a conserved cis element, REX, and a [C/T]AATTA homeodomain motif signature that are necessary and sufficient to convert short- and medium-range limb enha...
16 Jul 202516min
️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian
️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage whole-genome sequence recovered from a high-status individual...
15 Jul 202513min
75: How Metabolism Shapes Enzyme Structures Over 400 Million Years
Lemke O et al., Nature - A deep structural and evolutionary analysis of 11,269 enzyme structures across Saccharomycotina reveals how metabolic context sculpts protein architecture. The study integrate...
14 Jul 202514min
74: Benchmarking TCR-epitope predictors with ePytope-TCR
Drost F et al., Cell Genomics - Drost et al. integrated 21 pre-trained sequence-based TCR-epitope predictors into ePytope-TCR and benchmarked them on a viral single-cell repertoire and deep mutational...
13 Jul 202520min
73: Family history and genetics in dementia
König T et al., Genetics in Medicine - A retrospective study of 701 memory clinic patients tested whether stratifying by age at onset and family history enriches for diagnostically relevant genetic fi...
12 Jul 202515min
