The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episoder(1464)

Aging Starts In Your Legs (Here’s The Fix) : 1408

Aging Starts In Your Legs (Here’s The Fix) : 1408

Most people think aging starts with wrinkles, gray hair, or memory loss. It doesn’t.Aging starts when your legs begin to weaken, long before you notice it.In this video, you’ll learn why your leg musc...

1 Feb 8min

The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407

The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. ...

30 Jan 1h 4min

Meet the Governor Who Wants Humans to Become Cyborgs  : 1406

Meet the Governor Who Wants Humans to Become Cyborgs : 1406

Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn California into the global test bed for radical human...

29 Jan 1h 7min

Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon  : 1405

Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you’ll learn why ...

27 Jan 1h 2min

The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.In this video, I explain how appetite is actually regulated, why synthetic shortcuts often ...

25 Jan 22min

Biohacking News Weekly Update : 1403

Biohacking News Weekly Update : 1403

This episode covers: • Real Food Reset in U.S. Dietary Policy The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ul...

23 Jan 9min

This Brain Trick Feels Like Cheating (Do THIS)  : 1402

This Brain Trick Feels Like Cheating (Do THIS) : 1402

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia...

22 Jan 1h 13min

Inside the Mind of the Mad Scientist Rewriting Aging  : 1401

Inside the Mind of the Mad Scientist Rewriting Aging : 1401

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understa...

20 Jan 42min

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