The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Episoder(1561)

The 'Secret Sauce' To A 10/10 Morning Routine  : 1490

The 'Secret Sauce' To A 10/10 Morning Routine : 1490

Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood...

25 Jun 38min

The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489

The Biohacking Secrets of Dubai | Dr. Elie Abirached : 1489

Longevity, Trauma Recovery, Circadian Health, Ramadan Fasting & Biohacking Your nervous system may be aging you faster than your diet. Learn how childhood programming, stress, sleep, fasting, resilien...

23 Jun 25min

It's Weird, But It Turns On Your Body's Anti-Aging Switch Fast : 1487

It's Weird, But It Turns On Your Body's Anti-Aging Switch Fast : 1487

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/If you're eating clean, taking the right supplements, and still ...

21 Jun 15min

Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1488

Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1488

Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut micr...

19 Jun 11min

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin   : 1486

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the tr...

18 Jun 1h 1min

The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher  : 1485

The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485

Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to ...

16 Jun 44min

Just 1 Gram Activates Your Deep Focus Switch (Take THIS) : 1484

Just 1 Gram Activates Your Deep Focus Switch (Take THIS) : 1484

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I’ve built companies and spent millions ...

14 Jun 11min

World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more...  : 1483

World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more... : 1483

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigen...

12 Jun 11min

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