The Human Upgrade: Biohacking for Longevity & Performance

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Powerhouse Mushrooms: https://lifecykel.com, use code ASPREY25 to save 25%Track Your Health: https://info.insidetracker.com/dave, sign up to get your promo code for 25% off storewideSupplement Bioavailability: https://www.quicksilverscientific.com, use code DAVE15 to save 15% on your first order IN THIS EPISODE OF BULLLETPROOF RADIO...…you’ll learn that being adaptive to change is a skill you can cultivate. One of the most sustainable ways to keep going with the flow is knowing how to build emotional awareness. These two guests give tips on managing your emotional states so you can be more resilient in all areas of your life.Expert psychologist, trainer and speaker Joan Rosenberg, Ph.D., guides yoou to achieve your highest potential by teaching you how to be in control of your own emotions. Award-winning Harvard Medical School psychologist Susan David, Ph.D., describes all the psychological skills necessary for you to thrive in uncertain times. She challenges the common attitude that you have to “fix” your difficult emotions through positive thinking. “Emotional agility is about the capacity to be with ourselves,” Susan says. “That includes our difficult thoughts and emotions and stories and past experiences in a way that's compassionate and curious and that doesn't hold us back from being the people that we most want to be.”Since you can’t get away from emotions, there’s power in knowing how to deal with them. “We've got to be able to reconnect with ourselves so that we can move forward in the world,” Susan says.Get ready to learn some foundational skills that will make you an emotional agility pro.About Joan: The author of “90 Seconds to a Life You Love: How to Master Your Difficult Feelings to Cultivate Lasting Confidence, Resilience, and Authenticity,” teaches you how to be in control of your own emotions.Joan guides you through eight unpleasant feelings she’s pinpointed: sadness, shame, helplessness, anger, vulnerability, embarrassment, disappointment and frustration. She says the best way to approach these feelings is with confrontation and empathy.“The single most important thing I can do is to recognize someone’s pain, and just in essence, hold a mirror up to it, even if it sounds like you’re saying the things that are so obvious,” Joan says. “It has a huge impact of calming someone else’s nervous system down.”About Susan: She’s the author of “Emotional Agility: Get Unstuck, Embrace Change, and Thrive in Work and Life,” based on 20 years of research of how to get through uncertainty “For people to be healthy with themselves, with the inner worlds, these are not soft skills,” Susan says. “These are the most fundamental skills that we can have as human beings.” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Des 202138min

In this Episode of The Human Upgrade™...Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Beer & blue cheese found in ancient fecesBlood marker detects dementia earlyTeam flow shows up as a unique brain stateTrauma-focused psychotherapy works for PTSDMDMA improves PTSD symptoms EPISODE SPONSOR: All your cells require minerals to function. Fulvic and humic complexes provide cellular nutrition to support detoxification. Go to https://www.beamminerals.com and use code DAVE20 to get 20% offLISTEN: "Follow" or "subscribe" to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Des 202110min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Sleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discountControl Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentSubscription Box for Biohackers: Each season (and limited editions, too!) discover and enjoy innovative wellness products, hand-curated by Dave Asprey, that you may not find anywhere else. https://daveaspreybox.comSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSVisit https://getmyphoenix.com/dave and use code DAVE100 to save $100.IN THIS EPISODE OF THE HUMAN UPGRADE™… …urologist, surgeon and age medicine specialist Dr. Paul Thompson discusses the challenges men can experience with their sexual health, energy and performance. Erectile dysfunction happens to men at all ages and is actually quite normal. Causes can be physical, and hormones play a role. Nutrition or exercise habits may be culprits. And state of mind factors in.Dr. Thompson shares his clinical expertise on how getting to the root of what’s going on with men's sexual functioning will not only improve erectile dysfunction but also support other critical areas of men’s health. The conversation looks at the pros and cons of eating meat, what your cholesterol numbers really mean, and why cardiovascular health matters at every age.Guys, listening to this, if your doctor isn't asking you for Lp-PLA2, which is an enzyme that's expressed when there's damage to your arteries, then you have a problem. If they aren't looking at C-reactive protein, you have a problem; and if they're not looking at homocysteine, you have a problem. So, you could ask your doctor for them or you could ask your doctor, “Hey, what do you know about these?”You’ll also find out why oral health is so important and why you have to pay attention to your nitric oxide production.Dr. Thompson talks about the at-home device he helped develop at Launch Medical (he’s chief medical officer there) that's pioneering a solution for erectile dysfunction. It’s based on clinical acoustic wave therapy treatment. “Acoustic wave is really simple and it works, and it has to do with the growth of blood vessels,” he explains. The Phoenix device helps men improve and/or restore their sexual functioning.Guys and women who love guys or guys who love guys, this thing is real technology. It does work, it is not too good to be true, and it's worth talking about.This conversation takes any embarrassment or shame out of the ED equation and gets into the details of plaque, blood flow and how you can find a fix and reclaim your sexual health.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Des 20211h 25min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!High-Performance Leadership: https://www.humanpotentialinstitute.com/coach-training/Track Your Health: https://info.insidetracker.com/dave, sign up to get your promo code for 25% off storewideSupplement Bioavailability: https://www.quicksilverscientific.com, use code DAVE15 to save 15% on your first order SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSVisit https://apolloneuro.com/DAVE10 to get 10% off an Apollo Neuro device.IN THIS EPISODE OF THE HUMAN UPGRADE™…...you'll learn about the impact of chronic stress in humans, how it wrecks your sleep and what you can do about it.For more than a decade, neuroscientist, board-certified psychiatrist, health tech entrepreneur and inventor David Rabin (an M.D. and Ph.D.) has been immersed in the science of stress. He’s been researching causes and ways to manage it. He’s also been helping people deal with the consequences of both acute and chronic stress.He’s back on the show (don’t miss episodes #729 and #730) to talk about how stress disturbs systems of your body and mind, which, of course, affects your sleep.Stress is not inherently bad because we require it to grow, Dr. Rabin says. “We require the stress to help us learn how to overcome the challenges that are signaled by the stress to become better, stronger, fuller versions of ourselves.” … “There are the situations where we start to see acute stress that can be healthy and very helpful to growth turn into chronic stress,” he continues. “And that chronic stress increases inflammation on a daily basis. It’s that chronic stress that increases likelihood of disease.”Dr. Rabin co-founded Apollo Neuroscience, a company that developed the first scientifically validated wearable technology that actively improves energy, focus and relaxation. This tech uses a novel touch therapy that signals safety to the brain. In new studies, it’s had a terrific impact on stress and sleep.“Health means the restoration and maintenance of balance for all of us,” Dr. Rabin says. “Critically important is managing our sleep and our circadian rhythms, and our sleep and wake cycles. Maintaining sleep and making sure we do things to have a healthy sleep rhythm is going to maximize our performance and energy availability during the day and psychedelic medicines and wearables can play as important to role in that for us as the day-to-day practices of breathwork and meditation, yoga, exercise and nutrition.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Des 20211h 10min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Get Salty AF: https://drinklmnt.com/dave, get the LMNT sample pack for the cost of shipping, $5. (If you like it, try the new limited edition Mint Chocolate flavor for the holidays!)Unlock Your Brain with Customized Nootropics: https://nootopia.com/dave, use code DAVE10 to save 10% on your first order Track Blood Glucose: https://www.levelshealth.com/DAVE, sign up for the Beta groupSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSGo to https://www.quicksilverscientific.com and use code DAVE15 to save 15% all products.IN THIS EPISODE OF THE HUMAN UPGRADE™… … Christopher Shade, Ph.D., joins the show to take you through a new six-spoke “longevity wheel.” You’ll find out what you can do to live longer by managing toxins and hormones that influences aging.With expertise in environmental sciences, chemistry and biology, he founded the Colorado-based company Quicksilver Scientific. It’s a group of “chemists, biohackers and age rebels.”He specializes in the biological, environmental, and analytical chemistry of mercury in all its forms. He presents and teaches in the U.S. and nationally about mercury, environmental toxicities, neuroinflammation, immune dysregulation, and the human detoxification system.He's designed detoxification protocols, unique supplement delivery systems, and a patented mercury speciation test. As CEO, he continually drives development and innovation. Right now, the focus is longevity with a foundation in detoxification.Everyone has a meaningful amount of metals, plastics, molds or other toxins in their body and is pretty much operating with low-grade toxicity. And even though everyone has the same basic detoxification system, people react to and process toxins very differently. There’s a general universe of toxins: You have exogenous toxins from outside the body (metals, chemicals, mycotoxins or food-borne toxins). Then you have endotoxins, which are made on board usually by gut bacteria and lipopolysaccharide.That’s why cellular level detoxification matters so much. Bile flow, and knowing what blocks it and what opens it, plays a huge role in your body’s detoxification process.If you learn to think like a computer or especially a network engineer, there's a whole bunch of interrelated systems. If one of them is broken, it'll have an effect on the other. But when you look at detox pathways, you look at aging, it's a very similar mindset, way more so than you would think.Hormones, too, get in on the aging action. DHEA and pregnenolone are the mother hormones. All the other hormones are made out of those two things. “Hormones are necessary for all the detox reactions,” Chris says. “Having the right levels of all the hormones just powers everything up.”The six-spoke “Longevity Wheel” framework that Chris developed biohacks conventional aging assumptions. This wheel is a collection of biochemical pathways, mechanisms, and molecules that impact aging. Each spoke builds on another and all work together. Nrf2 and AMPKNADSirtuinsTelomeresSenolyticsNeuroendocrineListen on to find out more about how detox, hormones and the spokes of this new Longevity Wheel can impact how you age.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Des 20211h 17min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 for 15% offSupport Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offEat Good Keto Bread: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundle. That includes two superfood cubes and a four pack of freedom chips!SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSYou can order TRUAGE at https://trudiagnostic.com/dave-asprey and enter code ASPREY at checkout for $50 off.IN THIS EPISODE OF THE HUMAN UPGRADE™… …you’re going to discover how old you really are by taking a dive into the science of epigenetic methylation and biological aging. You’re going to find out about gene function, gene expression and what it has to do with how you age—and why it matters.Biochemist Ryan Smith co-founded TruDiagnostic, a company focused on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic, a CLIA certified lab and health data company, developed the TRUAGE anti-aging test. From a small blood test, TruDiagnostic can tell you your biological age—how old your body acts, based on how it’s functioning (as opposed to your chronological age, which is the number of years you’ve been on Earth). Biological age is one of the most impactful pieces of data you can have about yourself. Age is the number one predictor of death, and your biological age matters more than the number of times you’ve been around the sun. For example, you could be 42, and if you take great care of yourself, your biological age may be 30… Or, if you take poor care of yourself, your biological age may be 60. Either way, TruDiagnostic will tell you how old you really are. And their test goes further than that. After you discover your biological age, TruDiagnostic also gives you a list of strategies to reverse aging based on your unique genetics. In other words, you get personalized anti-aging biohacks—and you can test your age over time to see if you’re getting younger, so you know whether or not your anti-aging hacks are working.If you can turn back the clock on your biological age, you unlock the door to a longer, better life. It feels like the cusp of a big change in longevity research with science and data now more fully supporting this work. TruDiagnostic currently has over 30 approved clinical research studies underway investigating how epigenetic methylation changes impact how long you live and how well you age.In this episode, you’ll also learn:Why men age worse than women, and what you can do about itThe best ways to predict your biological age (hint: grip strength is one of them)How getting COVID changes the speed at which you ageWhy small amounts of stress are amazing for anti-aging (and the right ways to stress your body and brain so you age in reverse)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Des 20211h 16min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cardiovascular Health: https://arterosil.com/dave20/, get a 3-pack and save up to 30% plus free shippingHealth Upgrades with Custom Lab Testing and Your Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipTrack Blood Glucose: https://www.levelshealth.com/Dave, sign up for the Beta groupSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSGo to https://pendulumlife.com and use promo code DAVEVIP to get an exclusive discount. IN THIS EPISODE OF THE HUMAN UPGRADE™… …we get into the gut. If you’ve listened to my podcast before you probably know how much the gut is a culprit in disease. I’ve invited experts on the show to explain how without the right balance of good bacteria in your gut, you can have inflammation, poor immune response, GI distress and much more. Your gut lining is like a fence, explains Colleen Cutcliffe, Ph.D. It needs maintenance and attention, because that “fence” is what guards your gut from bad bacteria and toxins. Without it, you lose a strong defense system.That’s where Akkermansia comes in. This bacterial strain naturally found in the gastrointestinal tract helps regulate the mucus lining of the gut, while also fine-tuning immune responses. Only in recent years have people understood (and acted on) the gut microbiome’s role in wellness or disease. Dr. Cutcliffe shares the research behind Akkermansia and why this probiotic is changing the gut health game.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Nov 202153min

In this Episode of The Human Upgrade™...Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Migraines diminish the quality of your deep and REM sleep.Microbiome bacteria can either help or harm people with Type 2 Diabetes.A safer contraception option for men means no testicle injections.Kids learn to manage big emotions by playing specially designed video games..New studies show 6.5 hours of sleep could be surprisingly good for you.EPISODE SPONSOR: Control Blood Glucose with Pendulum. Visit https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipment.LISTEN: "Follow" or "subscribe" to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.JOIN: Learn directly from Dave Asprey alongside others in a membership group: https://ourupgradecollective.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Nov 202111min