10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Sleep, Sex & Tech at the Bulletproof Conference

Sleep, Sex & Tech at the Bulletproof Conference

On this special episode of Bulletproof Radio, we take a look at a couple of conversations that took place during last year's Bulletproof Conference. First, "Orgasm Expert" Eli Block of OneTaste answers a Q&A with a focus on OMing and Bulletproof sex. Next, we get to hear Dave speak to the audience about sleep tracking and other sleep hacks, along with the tech soon to be featured at Bulletproof Labs. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Juli 201655min

Diving into the Fountain of Youth with Aubrey de Grey

Diving into the Fountain of Youth with Aubrey de Grey

Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA. He is the Chief Science Officer of SENS Research Foundation, a California-based biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. On today's episode of Bulletproof Radio, Dave and Aubrey talk about the seven things that cause aging, morbidity, the ethics of immortality, fighting cancer, aging goals for the immediate future and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Juli 201659min

Keying in on Ketones with Dominic D'Agostino

Keying in on Ketones with Dominic D'Agostino

Dr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and Senior Research Scientist at the Institute for Humans and Machine Cognition (IHMC). His research is focused on developing and testing ketogenic diets, ketone supplements and amino acid formulations for a broad range of therapeutic and performance applications. Dom previously appeared on Bulletproof Radio to talk about mastering ketosis, and he's back with more great information. Today Dave and Dom talk about mitochondrial efficiency, chronic diseases, increasing ketones, ketone salts and esters, mitochondrial physiology, the Krebs cycle and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Juli 20161h 5min

Live from London: Tech Hacks, Gut Bacteria, Positive Energy & More

Live from London: Tech Hacks, Gut Bacteria, Positive Energy & More

Description not available at this time, check back later See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Juli 20161h 25min

Taking on the USDA One Penny at a Time with Gunnar Lovelace

Taking on the USDA One Penny at a Time with Gunnar Lovelace

Gunnar Lovelace is a serial entrepreneur in nonprofits, technology, fashion and real estate. Most recently he is the founder and co-CEO of Thrive Market, an online wholesale buying club on a mission to make healthy living easy and affordable for every American family. On this episode of Bulletproof Radio, Dave and Gunnar talk about food co-ops, marketing healthy food, food politics, the grocery supply chain, the power of your vote, McDonalds and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Juli 201656min

June Q&A: Psoriasis, Soda Replacements, Alternative Education & More

June Q&A: Psoriasis, Soda Replacements, Alternative Education & More

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted through our voicemail, Facebook and the Bulletproof® Forums, for a great May Q&A. Listen to Dave and Bulletproof Coach trainer Dr. Mark Atkinson talk about psoriasis, sparkling mineral water and other soda replacements, depression, Waldorf schools, Brain Octane serving suggestions, plateaus in weight loss and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Juni 201652min

His & Hers Hormones with Dr. Tami Meraglia

His & Hers Hormones with Dr. Tami Meraglia

Dr. Tami Meraglia is a double board certified physician in Aesthetic Medicine and Integrative & Natural Medicine. Dr. Tami is passionate about creating natural aesthetic results in her patients. Additionally, she can help discover and correct any medical conditions, hormonal deficiencies, or hormonal imbalances that help people feel and look more beautiful and energetic. On today's episode of Bulletproof Radio, Tami and Dave talk about testosterone and other adrenal hormones, libido advice, birth control, DHEA preferences, fat for kids and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Juni 20161h 9min

From Rock-Bottom to Rock-Hard Abs with Natalie Jill

From Rock-Bottom to Rock-Hard Abs with Natalie Jill

Natalie Jill is the author of 7 Day Jump Start - Unprocess Your Diet, and helps people across the globe reach their health, fitness, and business goals. Natalie leveraged the power of the Internet and created a globally recognized brand with over two million social media followers, leading to an online business that has generated over 7-figures in revenue! Many see Natalie Jill as a fitness and nutrition expert, but she is increasingly garnering attention for her ability to help others create, define, and monetize their brand in the online space. On today's episode of Bulletproof Radio, Dave and Natalie talk about breakfast, social media, unprocessed foods, gluten-free definitions, willpower and getting into the fat-burning mode. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Juni 20161h 1min

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