10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

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• Upgrade Collective: https://www.ourupgradecollective.com

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• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Avsnitt(1431)

Downward Dog Like a Real Life Warrior One with Mark Divine

Downward Dog Like a Real Life Warrior One with Mark Divine

Mark Divine is a retired SEAL with 20 years of service and a best-selling author. He's drawn on his SEAL experience to develop exercise and leadership teachings, notably detailed in his book The Way of the SEAL. This serves as Mark's second appearance on Bulletproof Radio, and follows the release of his latest work, Kokoro Yoga: Maximize Your Human Potential and Develop the Spirit of a Warrior--the SEALfit Way. On today's episode of Bulletproof Radio, Dave and Mark talk about the differences between Kokoro and Ashtanga yoga, combat stress, kryptonite, meditation, visualization, flexibility and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Juni 20161h 5min

Why We Need to KO the GMO with Don Huber

Why We Need to KO the GMO with Don Huber

Dr. Don Huber, Professor Emeritus of Plant Pathology at Purdue University, holds B.S. and M.S. degrees from the University of Idaho, a Ph-D from Michigan State University, and is a graduate of the US Army Command & General Staff College and Industrial College of the Armed Forces. He was Cereal Pathologist at the University of Idaho for 8 years before joining the Department of Botany & Plant Pathology at Purdue University in 1971. His agricultural research the past 55 years has focused on the epidemiology and control of soilborne plant pathogens with emphasis on microbial ecology, cultural and biological controls, nutrient-disease interactions, pesticide-disease interactions and techniques for rapid microbial identification. On today's episode of Bulletproof Radio, Dave and Dr. Huber talk about glyphosates, GMOs, natural mycotoxins, fertility, concerns for the global population, biological system and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Juni 20161h 23min

Rocking the Spectrum with Joe Biel - #317

Rocking the Spectrum with Joe Biel - #317

Joe Biel is a self-made publisher and filmmaker who draws origins, inspiration, and methods from punk rock. He is the founder/manager of Microcosm Publishing and co-founder of the Portland Zine Symposium. Joe is the author of Good Trouble: Building a Successful Life & Business on the Spectrum. On this episode of Bulletproof Radio, Dave and Joe talk about growing up with Asperger's, learning values from punk rock, succeeding in business on the spectrum, stress management, quality books, repairing the publishing system and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Juni 20161h 4min

Steven Breitbach & Maryam Henein: Honey, We Shrank the Bees - #316

Steven Breitbach & Maryam Henein: Honey, We Shrank the Bees - #316

Maryam Henein and Steve Breitbach come to Bulletproof Radio as experts in the world of bees. Maryam is a journalist and founder of HoneyColony, an online community of healthy, quality food advocates. She also directed Vanishing of the Bees, a documentary exploring the causes and effects of bee colony collapses worldwide. Steven is a natural foods entrepreneur. He founded HiveMind Bee Pollen, a premium brand of pollen sourced from ethical, family run California apiaries. On today's episode of Bulletproof Radio, the duo and Dave talk about pollen, pesticides, product labeling, allergies and treatments, cheap and raw honey, royal jelly and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Juni 20161h 1min

Daniel DeBaun: Keeping Your Lady & Man Parts Safe... From EMF - #315

Daniel DeBaun: Keeping Your Lady & Man Parts Safe... From EMF - #315

Daniel DeBaun is a leader in shielding electronic emissions and protecting our bodies from potentially harmful radiation. He's spent his career as a technical expert in telecommunications, and now is highly focused on the electromagnetic field (EMF) radiation exposures from electronic devices. Daniel serves as CEO of DefenderShield, a health and wellness technology company that has created the most effective EMF protection solutions ever developed. On today's episode of Bulletproof Radio, Dave and Daniel talk about EMF emissions, Bluetooth vs. Wifi, European radiation standards, fallacies regarding EMR and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201655min

Mark Sisson: Get Primal on Your Cardio- #314

Mark Sisson: Get Primal on Your Cardio- #314

Health and fitness expert Mark Sisson is the bestselling author of The Primal Blueprint and one of the leading voices of the Evolutionary Health Movement. His blog, MarksDailyApple.com, has paved the way for Primal enthusiasts to challenge conventional wisdom's diet and exercise principles and take personal responsibility for their health and well-being. Mark's efforts to promote primal living extend to a line of nutritional supplements, a book publishing company, a Primal Kitchen line with healthy mayonnaise, salad dressing, meal replacement and energy bar, and a burgeoning Primal Kitchen fast casual restaurant chain. His new book Primal Endurance applies the primal eating and lifestyle principles to the challenge of endurance training-helping athletes overcome the common conditions of burnout and carbohydrate dependency. We're also happy to announce that Mark will be speaking at the 2016 Bulletproof Conference! On today's episode of Bulletproof Radio, Mark and Dave talk about Primal Endurance, training routines, testosterone, calories, ketosis, stem cells, over-nutrition and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Maj 20161h 5min

Erin Oprea - Tabatas: Like Getting HIIT by a 4x4 - #313

Erin Oprea - Tabatas: Like Getting HIIT by a 4x4 - #313

Erin Oprea is a former Marine of nine years, including two tours in Iraq. She lead the first all-female platoon attached to the infantry in a war zone and now is a trainer for over ten years with celebrity clients Carrie Underwood, LeeAnn Womack, Kellie Pickler, Jana Kramer and Jennifer Nettles, just to name a few. She is the author of The 4x4 Diet, which helps people focus their eating in four key areas and create workouts based on Tabata timing for great results. On today's episode of Bulletproof Radio, Dave and Erin talk about endurance training, high-intensity training, toxic foods, her work with celebrities, her experiences in Iraq, writing a recipe book and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Maj 201658min

May Q&A:  Sinuses, Teens, Depression & Dave's Last Meal on Earth - #312

May Q&A: Sinuses, Teens, Depression & Dave's Last Meal on Earth - #312

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted through our voicemail, Facebook and the Bulletproof® Forums, for a great May Q&A. Listen to Dave and Bulletproof Coach trainer Dr. Mark Atkinson talk about daily eating habits, meals for the last day on Earth, sinusitis and mold, Bulletproof Coffee for teens and more. This episode covers a variety of topics based on your questions. Thank you and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Maj 201647min

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