The Human Upgrade: Biohacking for Longevity & Performance

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. Enjoy!Here’s the current lineup for episode #6:Lonely brains crave people.A new drug reverses age-related cognitive decline super quick.Repetitive behaviors and gut problems may be related.Degenerative diseases progress in two distinct phases.Sensitivity to oxidative stress increases without enough sleep.Farming on Mars is about more than poop.EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms. https://eng3corp.com/DAVE/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Des 202013min

In this episode of Bulletproof Radio, my guest Dr. Elizabeth Yurth explains how spermidine, a substance found in the human body and almost all plants and animals, can slow down the cellular aging process and influence your overall health.“Where we see spermidine work is at a very, very base level to correct the autophagy to get rid of those bad mitochondria so that now we're not being overwhelmed by reactive oxygen species,” Dr. Yurth says. “We actually will start to recycle the bad parts of the cell and start with a new cell at that point.” Dr. Yurth is medical director/chief medical officer at Boulder Longevity Institute, and a partner with Longevity Labs+, the company that’s been pioneering spermidine research for the last decade and focuses their research on the improvement of aging. So what does spermidine do? Most importantly, it regulates a cell renewal process called autophagy, one of the most touted benefits of fasting.Spermidine helps you take control of the aging process.SpermidineLIFE® is the first naturally extracted and clinically tested dietary supplement to promote cellular renewal after multiple studies, trials and 10 years of research.People in clinical trials reported better memory, better sleep, more energy, reduced brain fog, improved skin and hair, and more. “Spermidine’s working on so many pathways to reduce reactive oxygen species, to improve the immune health, and to reduce the inflammatory cytokines that we know are initiated in these disease processes,” Dr. Yurth says.Spermidine is an important part of the body’s cellular processes that:Support healthy cell agingHave preventive effects on age-related diseasesIncrease life expectancy and liver protectionPromote healthy weightNormalize bone densityReduce age-dependent muscular atrophyEnhance growth of hair, skin, and nails“Every single species, every one-cell organism. Everybody has this, so we know it’s critical to life," Dr. Yurth says. "We absolutely know it’s critical to life.”Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/BULLETPROOF RADIO LISTENER SPECIAL OFFER: Go to https://spermidinelife.us/dave, use code DAVE25 for 25% off your first purchaseWE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Light Therapy: https://joovv.com/pages/dave-asprey; use code DAVEFitness Tech: https://www.fitbit.com/global/us/home; six FREE months of Fitbit Premium with the purchase of a Fitbit SenseNature’s Nootropic: https://gettrukava.com, use code DAVE15 for 15% offSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Des 202059min

In this episode of Bulletproof Radio, I’ve invited two experts who know a lot about plants and how plants interact with our cell biology. We discuss the exciting new discovery of a molecule called Urolithin A that’s a breakthrough in mitochondrial health. Urolithin A promotes mitochondrial function, muscle strength and longevity. Navindra Seeram, Ph.D., is professor and chair of the Department of Biomedical and Pharmaceutical Sciences at the University of Rhode Island and is one of the most highly cited scientists in Agricultural Sciences.With a background in cell and molecular biology, biomedical engineering and engineering, Chris Rinsch, Ph.D., has been immersed in the biotech and life sciences industry for more than two decades. Our conversation centers on Mitopure™, the first clinically tested Urolithin A available through Timeline Nutrition.One of the most important things Urolithin A does is revitalize the energy factories inside our cells. Each of our cells contain mitochondria, and the cell has an innate process of cleaning up the damaged mitochondria and recycling them. This process is called mitophagy. Urolithin A supports cellular health by stimulating mitophagy to keep cells fit and running efficiently.“It's really important to keep your mitochondria at its peak performance,” Chris says, “no matter what your general health conditions are.”Urolithin A is generated by the gut microflora as a natural food metabolite of ellagitannins, a class of compounds found in the pomegranate and other fruits, nuts and tea. Their studies have shown some pretty amazing results.“We saw that when we started incubating and feeding worms with Urolithin A they were increasing their lifespan by about 50 percent,” Chris says. “And when the studies moved to mice, they ran 40 percent further and longer after taking the Urolithin A.”Listen on to find out more about how Urolithin A is such a breakthrough for mitochondrial health and how it’s a game changer for cellular nutrition.Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/BULLETPROOF LISTENER SPECIAL OFFER: Go to https://www.timelinenutrition.com/DAVE and use code Dave 10 to get 10% off.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Build Immunity: https://leakygutguardian.com/dave, use code DAVE10 to save 10% on the Bulletproof Gut StackNature’s Nootropic: https://gettrukava.com, use code Dave15 for 15% offSEO Skills: https://www.stephanspencer.com, use code DAVE for a special discountSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Des 202052min

In this episode of Bulletproof Radio, my guest Lisa Wimberger was struck by lightning at age 15 and lived. That lightning strike set in motion a grand mal seizure disorder that she lived with for the next two decades and ultimately influenced her life’s work with neuroplasticity.The seizures became life threatening, but that condition inspired her to find ways to protect and rebuild her body and mind. She went on to explore neuroplasticity, a process that helped her to disrupt her seizures.“There's a seizure halo from stress and maladaptive vagal tone and then there's a seizure. Well, there's a gap in space and time between those two things and it might be a fraction a second, but that is a response pattern that I've gotten really good at. Neuroplasticity says I can change those things. It doesn't tell me how exactly, but I'm going to figure it out. I had all of this meditation that I was not using for my well-being, and then all of the science, and I just backwards engineered.”The most profound insight she learned was that the way she was meditating was actually harmful to her. “When you hear the word meditation, it's not one size fits all,” Lisa says. “There's all different kinds and you have to know what works for your body.” Lisa founded the NeuroSculpting® Institute in Colorado, where she teaches people and organizations who suffer from stress disorders, including law enforcement teams. She created NeuroSculpting®, a 5-step meditation process that can help an individual release the grip of old patterns and entrain their brain to creating new and more supportive patterns, habits and behaviors. “The benefits are you still get to hack into your nervous system, and you get to file down the sharp edges of any thought that might have triggered you into arousal at any point in time, or you can create brand new thoughts,” she says. “Neuroplasticity doesn't care if it's an experience you've never had or an experience you've had. It only cares that you're programming it with buy-in, and it's going to store that in your mind as a pattern.”Lisa earned a master’s degree in Education, a Foundations Certification in NeuroLeadership, and certificates in medical neuroscience, visual perception, and the brain, and neurobiology. She’s written numerous books on neuroplasticity and stress management, including Neurosculpting: A Whole-Brain Approach to Heal Trauma, Rewrite Limiting Beliefs, and Find Wholeness and New Beliefs, New Brain: Free Yourself from Stress and Fear.She’s also co-creator of a digital app made up of interactive NeuroSculpting® modules that shift brain neuroplasticity and support well-being, called NeuroPraxis. This unique app helps people re-pattern trauma and nervous system suffering through guided meditation.Listen today as we talk about Lisa’s discoveries in brain entrainment, stress management and meditation practices that do no harm.Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Great Skin: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideCool Sleeping: https://chilitechnology.com/asprey, get 22% off sleep systems for a limited timeMood Control: Go to www.hapbee.com/dave, get $50 off the Hapbee device, which retails for $379See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Des 202059min

In this episode of Bulletproof Radio, my guest is Dr. Phil Wolfson, the creator of Ketamine Assisted Psychotherapy. He shares his vast knowledge about the benefits of ketamine, and other healing chemicals like mushrooms or MDMA, as a treatment for depression, PTSD, addiction and other conditions. Dr. Wolfson leads patients through psychedelic psychotherapy sessions, guiding them through their past and present in an open, altered state of mind.Dr. Wolfson is a specialist in psychedelic psychotherapy, a practicing Buddhist, and a “psychonaut.” His invaluable work is the result of an intense, many-decades-long clinical psychiatry/psychotherapy practice that focuses on new pathways for healing.“There's really no right or wrong with psychedelics,” Dr. Wolfson says. “They have special properties. People go through either a low dose or moderate to high dose experience. That experience is separated from your life here. And then the real work is the integration as people come back, [asking] How am I different? What have I learned from this?”For example, in the first hour of mushrooms or psilocybin, you're going to go through a psychological scrape, he says. “All the misdeeds, and things you owe to people, and how you've been hurt or hurt others.”“It's about how do we integrate our lives and relationship in this very difficult time with people and in our beings, and what practices we bring to this whole thing. So, it's not just about substances.”“We use our medicines in a sacred way,” Dr. Wolfson says. “We're not doing traditional medicine; we're not doing intravenous anesthesiology practices. We bring people in, we do invocation. We help people move into a state of contemplation before we do substances.”He’s also the CEO of the non-profit Ketamine Research Foundation, the director of the Center for Transformational Psychotherapy and a founding member of the Heffter Research Institute (HRI), a non-profit scientific organization. HRI has been helping design, review and fund the leading studies on psilocybin (the active ingredient in psychedelic mushrooms) at research institutions in the U.S. and Europe. Dr. Wolfson leads the newly founded Indra’s Net Coalition, which brings people around the world together in the midst of crisis for healing, self-expression and connection.“Indrasnetcoalition.org is a worldwide universal concept about connection,” he says. “It's about forming a network that is exists because we're all connected.” Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cleaner Teeth: www.davesdentalkit.comGood Meat: www.butcherbox.com/DAVEMood Control: Go to www.hapbee.com/dave and get $50 off the Hapbee device, which retails for $379See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Des 202058min

In this episode of Bulletproof Radio, I dive into an intriguing discussion about trauma with my guest, Rachel Yehuda, Ph.D. We touch on what her latest research is uncovering about the role epigenetics plays in trauma and how to identify signs of trauma in your own life. “Trauma affects everybody,” Rachel says. “Having a traumatic event will definitely change you in some way in terms of how you view the world.”RRachel is a professor and vice-chair of Psychiatry and professor of Neuroscience at Icahn School of Medicine at Mount Sinai in New York. Her work focuses on the fields of psychology, trauma, and epigenetic research. She has authored more than 300 high-cited journal articles and book chapters and developed fascinating insights about risk and resilience. Her research on cortisol and brain function has revolutionized the understanding and treatment of PTSD worldwide.With her in-depth knowledge of PTSD and epigenetics, Rachel walks us through how our parents' traumas can be passed down through the generations and how those triggers that you're working on today may not have originated in your lifetime. "It's not just that you carry the genes of your parents,” Rachel says. “You carry their history. You carry a lot of the sum total of their experiences."We also discuss:The often misunderstood role that cortisol plays in the stress response and how this "stress-hormone" may be better identified as an anti-stress hormone.How previously banned drugs like MDMA, DMT, and psilocybin may hold therapeutic potential for people working through traumas, and the road ahead for research into these drugs. The importance of finding the right practitioner to work with you on traumas that you may experience or have emerge in your life. Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Build Immunity: https://leakygutguardian.com/dave; use code DAVE10 to save 10% on the Bulletproof Gut StackLight Therapy: https://joovv.com/pages/dave-asprey; use code DAVEFitness Tech: https://www.fitbit.com/global/us/home; six FREE months of Fitbit Premium with the purchase of a Fitbit SenseSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Des 20201h 2min

In this episode of Bulletproof Radio, we take a look at how and why food allergies affect so many of us. Conquering mine has helped me immensely on my Bulletproof journey and I want to share a conversation that could help you do the same.Dr. Kari Nadeau is considered one of the world’s leading experts on food allergy, and is the author of the new book “"The End of Food Allergy, featuring Immunotherapy: The First Program to Prevent and Reverse a 21st-Century Epidemic". For more than 30 years she’s focused her expertise on the environmental and genetic factors that affect the risk of developing allergies and asthma, and the molecular mechanisms underlying the diseases. Allergies play a growing role in every part of our lives. They happen because of the products we put on our skin, the foods we eat every single day, and the products we use in our home and work environment. Dr. Nadeau offers ways to spot the allergens all around you.“We have the science,” Dr. Nadeau says. “We should do better and make people's quality of life better in general: on the therapy side, on the convention side, as well as on the diagnostic side.”Here are some quick allergy facts:One in three Americans has some form of allergies. It is estimated that one in 20 adults in America (5%) has a food allergy and 1 in 13 children in the U.S. suffers from food allergy The rate of people with food allergies is doubling approximately every 10 years. Adults with food allergies have a 65% chance of passing those allergies to their children. 90% of food allergies are caused by the following 8 allergenic foods: cow’s milk, soy, wheat, peanut, tree nuts, shellfish, fish, egg. “If you don't treat your body well within any given year, you might develop a food allergy,” Dr. Nadeau says. “You've got to take care of yourself because any one person can develop a food allergy newly, even if they didn't have an allergy before. This is a growing epidemic; it's just not a US-based disease anymore. It's growing around the world.” In the midst of a growing epidemic, Dr. Nadeau shares information about a potential upcoming treatment process that could help you find out what your allergies are, manage them if you already have them and potentially end them.Listen on to find out the differences between food sensitivities and allergies, thresholds for bodily stress, and ways we can both cure and prevent asthma and allergies. Dr. Nadeau answers all these questions and much more.Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Alternative Sweetener: https://www.lakanto.com, use code Dave15 to save 15% offCool Sleeping: https://chilitechnology.com/asprey, get 22% off sleep systems for a limited timeMood Control: Go to www.hapbee.com/dave and get $50 off the Hapbee device, which retails for $379See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Des 20201h 5min

In this episode of Bulletproof Radio, my guest is Colleen Cutcliffe, Ph.D., CEO and co-founder of Pendulum Therapeutics. We explore exciting new discoveries in the body’s gut microbiome and discuss how Pendulum is disrupting what we know about probiotics.Pendulum uses biological and computational insights into the microbiome to develop solutions for health and disease conditions. “Rather than calling a disease by what the symptoms are, we are actually looking at the microbiome as an underlying infrastructure within our body,” Colleen says. Pendulum also identifies and isolates new bacterial strains, then combines those new strains to create unique probiotics. These are backed by clinical research studies. Using this discovery platform, Pendulum created the world’s first microbiome intervention for people with Type 2 Diabetes. “Managing your blood sugar is at the core of so many health issues, including your immune system,” Colleen says. “You really are more vulnerable and susceptible when you're not managing your blood sugars properly.”In Pendulum’s clinical testing, they found out some interesting things.“We have people with type 2 diabetes on multiple drugs,” Colleen says. “We have people with pre-diabetes who are looking to avoid crossing over into taking drugs. And we've had people who are healthy that are really concerned about “how is my body metabolizing sugar and fibers.” And so we offer free A1c testing, actually at baseline, and then three months in so that people can see their results. And I think that really helps people kind of believe the results that they're experiencing.”Our conversation goes in a lot of directions related to the science of gut health–both your inner environment and the one around you. We’re learning so much, so fast, that science is seeing all sorts of connections. The gut microbiome is the frontier of how we’ll define better health.“Where we're heading is understanding that the microbiome is foundational in a lot of things like the immune response, allergies, digestion, metabolism, and that once you start to make sure that you have the right flora and all the right plants in your garden, you're actually going to be tackling a lot of these different things,” Colleen says. “And so, you won't have to have a specific thing for every disease because I think we're going to transform the way we think about disease.”Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/SPECIAL OFFER FOR BULLETPROOF PODCAST LISTENERS: Go to pendulumlife.com and use promo code "DAVE25" to get 25% off your first bottle.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cleaner Teeth: www.davesdentalkit.comNature’s Nootropic: https://gettrukava.com, use code Dave15 for 15% offSEO Skills: https://www.stephanspencer.com; use code DAVE for a special discountSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Des 202056min